Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition

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Title: Circulating insulin-like growth factor I in relation to melanoma risk in the European Prospective Investigation into Cancer and Nutrition
Authors: Bradbury, KE
Appleby, PN
Tipper, SJ
Travis, RC
Allen, NE
Kvaskoff, M
Overvad, K
Tjønneland, A
Halkjaer, J
Cevenka, I
Mahamat-Saleh, Y
Bonnet, F
Kaaks, R
Turzanski Fortner, R
Boeing, H
Trichopoulou, A
La Vecchia, C
Stratigos, AJ
Palli, D
Grioni, S
Matullo, G
Panico, S
Tumino, R
Peeters, PH
Bueno-de-Mesquita, B
Ghiasvand, R
Veierød, MB
Weiderpass, E
Bonet, C
Molina, E
Huerta, JM
Larrañaga, N
Barricarte, A
Merino, S
Isaksson, K
Stocks, T
Ljuslinder, I
Hemmingsson, O
Wareham, N
Khaw, K-T
Gunter, MJ
Rinaldi, S
Tsilidis, KK
Aune, D
Riboli, E
Key, TJ
Item Type: Journal Article
Abstract: Insulin-like growth factor (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case-control study of 1221 melanoma cases and 1221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity, and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth=0.93 (95% confidence interval (CI): 0.71 to 1.22)). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by sex, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma. This article is protected by copyright. All rights reserved.
Issue Date: 1-Mar-2019
Date of Acceptance: 25-Jul-2018
URI: http://hdl.handle.net/10044/1/62860
DOI: https://doi.org/10.1002/ijc.31854
ISSN: 0020-7136
Publisher: Wiley
Start Page: 957
End Page: 966
Journal / Book Title: International Journal of Cancer
Volume: 144
Issue: 5
Copyright Statement: © 2018 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: World Cancer Research Fund International
Funder's Grant Number: 2013/1002
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
melanoma
insulin-like growth factor I
height
EPIC
biomarker
prospective studies
CUTANEOUS MELANOMA
IGF-I
METAANALYSIS
INDEX
CELLS
EPIC
biomarker
height
insulin-like growth factor I
melanoma
prospective studies
Adult
Aged
Breast Neoplasms
Case-Control Studies
Europe
Female
Humans
Insulin-Like Growth Factor I
Male
Melanoma
Middle Aged
Nutritional Status
Odds Ratio
Prospective Studies
Prostatic Neoplasms
Risk Factors
Humans
Melanoma
Breast Neoplasms
Prostatic Neoplasms
Insulin-Like Growth Factor I
Odds Ratio
Risk Factors
Case-Control Studies
Prospective Studies
Nutritional Status
Adult
Aged
Middle Aged
Europe
Female
Male
EPIC
IGF-I
biomarker
height
insulin-like growth factor I
melanoma
1112 Oncology and Carcinogenesis
Oncology & Carcinogenesis
Publication Status: Published
Conference Place: United States
Online Publication Date: 2018-09-07
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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