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Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits

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Title: Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits
Authors: Evangelou, E
Warren, HR
Mosen-Ansorena, D
Mifsud, B
Pazoki, R
Gao, H
Ntritsos, G
Dimou, N
Cabrera, CP
Karaman, I
Fu, LN
Peters, A
Polasek, O
Pramstaller, PP
Quang, TN
Raitakari, OT
Ren, M
Rettig, R
Rice, K
Ridker, PM
Gaziano, JM
Gasparini, P
Ried, JS
Riese, H
Ripatti, S
Robino, A
Rose, LM
Rotter, JI
Rudan, I
Ruggiero, D
Saba, Y
Sala, CF
Giedraitis, V
Wilson, PWF
Salomaa, V
Samani, NJ
Sarin, A-P
Schmidt, R
Schmidt, H
Shrine, N
Siscovick, D
Smith, AV
Snieder, H
Gieger, C
Sober, S
Tsao, PS
Sorice, R
Starr, JM
Stott, DJ
Strachan, DP
Strawbridge, RJ
Sundstrom, J
Swertz, MA
Taylor, KD
Girotto, G
Teumer, A
Tobin, MD
Kovesdy, CP
Tomaszewski, M
Toniolo, D
Traglia, M
Trompet, S
Tuomilehto, J
Tzourio, C
Uitterlinden, AG
Goel, A
Vaez, A
Van der Most, PJ
Van Duijn, CM
Esko, T
Vergnaud, A-C
Verwoert, GC
Vitart, V
Volker, U
Vollenweider, P
Vuckovic, D
Gow, AJ
Watkins, H
Wild, SH
Willemsen, G
Wilson, JF
Magi, R
Wright, AF
Yao, J
Zemunik, T
Zhang, W
Attia, JR
Gudnason, V
Butterworth, AS
Chasman, DI
Conen, D
Cucca, F
Danesh, J
Milani, L
Hayward, C
Howson, JMM
Laakso, M
Lakatta, EG
Guo, X
Langenberg, C
Melander, O
Mook-Kanamori, DO
Palmer, CNA
Risch, L
Scott, RA
Almgren, P
Scott, RJ
Sever, P
Spector, TD
Gyllensten, U
Van der Harst, P
Wareham, NJ
Zeggini, E
Levy, D
Munroe, PB
Newton-Cheh, C
Brown, MJ
Boutin, T
Metspalu, A
Hung, AM
Hamsten, A
O'Donnell, CJ
Edwards, TL
Psaty, BM
Tzoulaki, I
Barnes, MR
Wain, LV
Elliott, P
Caulfield, MJ
Debette, S
Ding, J
Evangelou, M
Giulianini, F
Holliday, EG
Jackson, AU
Li-Gao, R
Lin, W-Y
Luan, J
Mangino, M
Oldmeadow, C
Prins, BP
Qian, Y
Harris, TB
Sargurupremraj, M
Shah, N
Surendran, P
Theriault, S
Verweij, N
Willems, SM
Zhao, J-H
Amouyel, P
Connell, J
De Mutsert, R
Harris, SE
Doney, ASF
Farrall, M
Menni, C
Morris, AD
Noordam, R
Pare, G
Poulter, NR
Shields, DC
Stanton, A
Thom, S
Hartman, CA
Abecasis, G
Amin, N
Arking, DE
Ayers, KL
Barbieri, CM
Batini, C
Bis, JC
Blake, T
Bochud, M
Boehnke, M
Havulinna, AS
Boerwinkle, E
Boomsma, DI
Bottinger, EP
Braund, PS
Brumat, M
Campbell, A
Campbell, H
Chakravarti, A
Chambers, JC
Chauhan, G
Hicks, AA
Ciullo, M
Cocca, M
Collins, F
Cordell, HJ
Davies, G
De Borst, MH
De Geus, EJ
Deary, IJ
Deelen, J
Del Greco, FM
Hofer, E
Demirkale, CY
Dorr, M
Ehret, GB
Elosua, R
Enroth, S
Erzurumluoglu, AM
Ferreira, T
Franberg, M
Franco, OH
Gandin, I
Hofman, A
Hottenga, J-J
Huffman, JE
Hwang, S-J
Witkowska, K
Ingelsson, E
James, A
Jansen, R
Jarvelin, M-R
Joehanes, R
Johansson, A
Johnson, AD
Joshi, PK
Jousilahti, P
Jukema, JW
Tzanis, E
Jula, A
Kahonen, M
Kathiresan, S
Keavney, BD
Khaw, K-T
Knekt, P
Knight, J
Kolcic, I
Kooner, JS
Koskinen, S
Hellwege, JN
Kristiansson, K
Kutalik, Z
Laan, M
Larson, M
Launer, LJ
Lehne, B
Lehtimaki, T
Liewald, DCM
Lin, L
Lind, L
Giri, A
Lindgren, CM
Liu, Y
Loos, RJF
Lopez, LM
Lu, Y
Lyytikainen, L-P
Mahajan, A
Mamasoula, C
Marrugat, J
Marten, J
Edwards, DRV
Milaneschi, Y
Morgan, A
Morris, AP
Morrison, AC
Munson, PJ
Nalls, MA
Nandakumar, P
Nelson, CP
Niiranen, T
Nolte, IM
Sun, YV
Nutile, T
Oldehinkel, AJ
Oostra, BA
O'Reilly, PF
Org, E
Padmanabhan, S
Palmas, W
Palotie, A
Pattie, A
Penninx, BWJH
Cho, K
Perola, M
Item Type: Journal Article
Abstract: High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
Issue Date: 17-Sep-2018
Date of Acceptance: 9-Jul-2018
URI: http://hdl.handle.net/10044/1/62366
DOI: https://dx.doi.org/10.1038/s41588-018-0205-x
ISSN: 1061-4036
Publisher: Nature Publishing Group
Start Page: 1412
End Page: 1425
Journal / Book Title: Nature Genetics
Volume: 50
Replaces: 10044/1/70810
http://hdl.handle.net/10044/1/70810
Copyright Statement: © 2019 Springer Nature Limited.
Sponsor/Funder: UNIVERSITY OF OULU
Commission of the European Communities
Home Office
Action on Hearing Loss
Imperial College Healthcare NHS Trust- BRC Funding
National Institute for Health Research
British Heart Foundation
Medical Research Council (MRC)
Medical Research Council (MRC)
Medical Research Council (MRC)
Medical Research Council (MRC)
UK DRI Ltd
National Institute for Health Research
National Institute for Health Research
Funder's Grant Number: Nil
201413
PG0484
G51_Chambers
RDF03
RTJ6219303-1
SP/13/2/30111
MR/L01341X/1
G0601966
MR/L01632X/1
MR/L01632X/1
4050641385
NF-SI-0513-10059
NF-SI-0513-10059
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
GENOME-WIDE ASSOCIATION
CARDIOVASCULAR RISK
HYPERTENSION
VARIANTS
METAANALYSIS
COMMON
HEALTH
RARE
HYPERALDOSTERONISM
PREVALENCE
Adult
Aged
Aged, 80 and over
Blood Pressure
Cardiovascular Diseases
Cells, Cultured
Female
Genetic Loci
Genetic Predisposition to Disease
Genetic Testing
Genetics, Population
Genome-Wide Association Study
Human Umbilical Vein Endothelial Cells
Humans
Hypertension
Life Style
Male
Middle Aged
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Risk Factors
Million Veteran Program
Cells, Cultured
Humans
Cardiovascular Diseases
Hypertension
Genetic Predisposition to Disease
Risk Factors
Life Style
Genetics, Population
Blood Pressure
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Adult
Aged
Aged, 80 and over
Middle Aged
Female
Male
Genome-Wide Association Study
Genetic Testing
Genetic Loci
Human Umbilical Vein Endothelial Cells
Developmental Biology
11 Medical and Health Sciences
06 Biological Sciences
Publication Status: Published
Online Publication Date: 2018-09-17
Appears in Collections:Mathematics
Statistics
National Heart and Lung Institute
Faculty of Medicine
Faculty of Natural Sciences
Epidemiology, Public Health and Primary Care



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