Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits

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Title: Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits
Author(s): Evangelou, E
Elliott, P
Tzoulaki, I
Pazoki, R
Karaman, I
Gao, H
Mosen-Ansorena, D
Evangelou, M
Jarvelin, M
Poulter, NR
Thom, SAM
Kooner, JS
Sever, PS
Chambers, JC
Item Type: Journal Article
Abstract: High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
Publication Date: 17-Sep-2018
Date of Acceptance: 9-Jul-2018
URI: http://hdl.handle.net/10044/1/62366
DOI: https://dx.doi.org/10.1038/s41588-018-0205-x
ISSN: 1061-4036
Publisher: Nature Publishing Group
Journal / Book Title: Nature Genetics
Sponsor/Funder: Home Office
UNIVERSITY OF OULU
Commission of the European Communities
Medical Research Council (MRC)
Action on Hearing Loss
British Heart Foundation
Medical Research Council (MRC)
Medical Research Council (MRC)
Medical Research Council (MRC)
National Institute for Health Research
Imperial College Healthcare NHS Trust- BRC Funding
UK DRI Ltd
Funder's Grant Number: PG0484
Nil
201413
G0601966
G51_Chambers
SP/13/2/30111
MR/L01632X/1
MR/L01632X/1
MR/L01341X/1
RTJ6219303-1
RDF03
N/A
Copyright Statement: © 2018 Springer Nature Limited. All rights reserved.
Keywords: Million Veteran Program
11 Medical And Health Sciences
06 Biological Sciences
Developmental Biology
Publication Status: Published online
Embargo Date: 2019-03-17
Online Publication Date: 2018-09-17
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine
Epidemiology, Public Health and Primary Care



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