Vitamin D receptor genotype influences risk of upper respiratory infection

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Title: Vitamin D receptor genotype influences risk of upper respiratory infection
Author(s): Jolliffe, DA
Greiller, CL
Mein, CA
Hoti, M
Bakhsoliani, E
Telcian, AG
Simpson, A
Barnes, NC
Curtin, JA
Custovic, A
Johnston, SL
Griffiths, CJ
Walton, RT
Martineau, AR
Item Type: Journal Article
Abstract: SNP in the vitamin D receptor (VDR) gene is associated with risk of lower respiratory infections. The influence of genetic variation in the vitamin D pathway resulting in susceptibility to upper respiratory infections (URI) has not been investigated. We evaluated the influence of thirty-three SNP in eleven vitamin D pathway genes (DBP, DHCR7, RXRA, CYP2R1, CYP27B1, CYP24A1, CYP3A4, CYP27A1, LRP2, CUBN and VDR) resulting in URI risk in 725 adults in London, UK, using an additive model with adjustment for potential confounders and correction for multiple comparisons. Significant associations in this cohort were investigated in a validation cohort of 737 children in Manchester, UK. In all, three SNP in VDR (rs4334089, rs11568820 and rs7970314) and one SNP in CYP3A4 (rs2740574) were associated with risk of URI in the discovery cohort after adjusting for potential confounders and correcting for multiple comparisons (adjusted incidence rate ratio per additional minor allele ≥1·15, P for trend ≤0·030). This association was replicated for rs4334089 in the validation cohort (P for trend=0·048) but not for rs11568820, rs7970314 or rs2740574. Carriage of the minor allele of the rs4334089 SNP in VDR was associated with increased susceptibility to URI in children and adult cohorts in the United Kingdom.
Publication Date: 28-Oct-2018
Date of Acceptance: 26-Jun-2018
URI: http://hdl.handle.net/10044/1/62274
DOI: https://dx.doi.org/10.1017/S000711451800209X
ISSN: 1475-2662
Publisher: Cambridge University Press (CUP)
Start Page: 891
End Page: 900
Journal / Book Title: British Journal of Nutrition
Volume: 120
Issue: 8
Copyright Statement: © 2018 The Authors. This paper has been accepted for publication and will appear in a revised form, subsequent to peer-review and/or editorial input by Cambridge University Press.
Keywords: Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
Vitamin D receptor
SNP
Upper respiratory infection
SINGLE NUCLEOTIDE POLYMORPHISMS
RANDOMIZED CONTROLLED-TRIAL
SYNCYTIAL VIRUS-INFECTION
ASTHMA EXACERBATIONS
DOSE VITAMIN-D-3
TRACT INFECTION
DOUBLE-BLIND
IN-VITRO
DISEASE
ASSOCIATION
25(OH)D
25-hydroxyvitamin D
C-C motif ligand
C-X-C motif ligand
CCL
CXCL
RSV
RV
URI
VDR
aGMR
aIRR
adjusted geometric mean ratios
adjusted incidence rate ratio
respiratory syncytial virus
rhinovirus
upper respiratory infection
vitamin D receptor
SNP
Upper respiratory infection
Vitamin D receptor
25(OH)D
25-hydroxyvitamin D
C-C motif ligand
C-X-C motif ligand
CCL
CXCL
RSV
RV
URI
VDR
aGMR
aIRR
adjusted geometric mean ratios
adjusted incidence rate ratio
respiratory syncytial virus
rhinovirus
upper respiratory infection
vitamin D receptor
SNP
Upper respiratory infection
Vitamin D receptor
0702 Animal Production
1111 Nutrition And Dietetics
0908 Food Sciences
Nutrition & Dietetics
Publication Status: Published
Conference Place: England
Embargo Date: 2019-08-22
Online Publication Date: 2018-08-22
Appears in Collections:National Heart and Lung Institute
Department of Medicine
Faculty of Medicine



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