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Investigating the impact of poverty on colonization and infection with drug-resistant organisms in humans: a systematic review

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Title: Investigating the impact of poverty on colonization and infection with drug-resistant organisms in humans: a systematic review
Authors: Alividza, V
Mariano, V
Ahmad, R
Charani, E
Rawson, T
Holmes, A
Castro Sanchez, EM
Item Type: Journal Article
Abstract: Background Poverty increases the risk of contracting infectious diseases and therefore exposure to antibiotics. Yet there is lacking evidence on the relationship between income and non-income dimensions of poverty and antimicrobial resistance. Investigating such relationship would strengthen antimicrobial stewardship interventions. Methods A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Ovid, MEDLINE, EMBASE, Scopus, CINAHL, PsychINFO, EBSCO, HMIC, and Web of Science databases were searched in October 2016. Prospective and retrospective studies reporting on income or non-income dimensions of poverty and their influence on colonisation or infection with antimicrobial-resistant organisms were retrieved. Study quality was assessed with the Integrated quality criteria for review of multiple study designs (ICROMS) tool. Results Nineteen articles were reviewed. Crowding and homelessness were associated with antimicrobial resistance in community and hospital patients. In high-income countries, low income was associated with Streptococcus pneumoniae and Acinetobacter baumannii resistance and a seven-fold higher infection rate. In low-income countries the findings on this relation were contradictory. Lack of education was linked to resistant S. pneumoniae and Escherichia coli. Two papers explored the relation between water and sanitation and antimicrobial resistance in low-income settings. Conclusions Despite methodological limitations, the results suggest that addressing social determinants of poverty worldwide remains a crucial yet neglected step towards preventing antimicrobial resistance.
Issue Date: 17-Aug-2018
Date of Acceptance: 9-Jul-2018
URI: http://hdl.handle.net/10044/1/62173
DOI: https://dx.doi.org/10.1186/s40249-018-0459-7
ISSN: 2049-9957
Publisher: BioMed Central
Journal / Book Title: Infectious Diseases of Poverty
Volume: 7
Copyright Statement: © The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Sponsor/Funder: National Institute for Health Research
National Institute for Health Research
NIHR knowledge mobilisation fellowship
Funder's Grant Number: HPRU-2012-10047
HPRU-2012-10047
KMRF-2015 04 007
Publication Status: Published
Article Number: ARTN 76
Appears in Collections:Department of Medicine (up to 2019)