Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort

Title: Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort
Authors: Matejcic, M
Lesueur, F
Biessy, C
Renault, AL
Mebirouk, N
Yammine, S
Keski-Rahkonen, P
Li, K
Hémon, B
Weiderpass, E
Rebours, V
Boutron-Ruault, MC
Carbonnel, F
Kaaks, R
Katzke, V
Kuhn, T
Boeing, H
Trichopoulou, A
Palli, D
Agnoli, C
Panico, S
Tumino, R
Sacerdote, C
Quirós, JR
Duell, EJ
Porta, M
Sánchez, MJ
Chirlaque, MD
Barricarte, A
Amiano, P
Ye, W
Peeters, PH
Khaw, KT
Perez-Cornago, A
Key, TJ
Bueno-de-Mesquita, HB
Riboli, E
Vineis, P
Romieu, I
Gunter, MJ
Chajès, V
Item Type: Journal Article
Abstract: There are both limited and conflicting data on the role of dietary fat and specific fatty acids in the development of pancreatic cancer. In this study, we investigated the association between plasma phospholipid fatty acids and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid composition was measured by gas chromatography in plasma samples collected at recruitment from 375 incident pancreatic cancer cases and 375 matched controls. Associations of specific fatty acids with pancreatic cancer risk were evaluated using multivariable conditional logistic regression models with adjustment for established pancreatic cancer risk factors. Statistically significant inverse associations were found between pancreatic cancer incidence and levels of heptadecanoic acid (ORT3-T1 [odds ratio for highest versus lowest tertile] =0.63; 95%CI[confidence interval]=0.41-0.98; Ptrend =0.036), n-3 polyunsaturated α-linolenic acid (ORT3-T1 =0.60; 95%CI=0.39-0.92; Ptrend =0.02) and docosapentaenoic acid (ORT3-T1 =0.52; 95%CI=0.32-0.85; Ptrend =0.008). Industrial trans-fatty acids were positively associated with pancreatic cancer risk among men (ORT3-T1 =3.00; 95%CI=1.13-7.99; Ptrend =0.029), while conjugated linoleic acids were inversely related to pancreatic cancer among women only (ORT3-T1 =0.37; 95%CI=0.17-0.81; Ptrend =0.008). Among current smokers, the long-chain n-6/n-3 polyunsaturated fatty acids ratio was positively associated with pancreatic cancer risk (ORT3-T1 =3.40; 95%CI=1.39-8.34; Ptrend =0.007). Results were robust to a range of sensitivity analyses. Our findings suggest that higher circulating levels of saturated fatty acids with an odd number of carbon atoms and n-3 polyunsaturated fatty acids may be related to lower risk of pancreatic cancer. The influence of some fatty acids on the development of pancreatic cancer may be sex-specific and modulated by smoking. This article is protected by copyright. All rights reserved.
Issue Date: 15-Nov-2018
Date of Acceptance: 9-Jul-2018
URI: http://hdl.handle.net/10044/1/62117
DOI: https://doi.org/10.1002/ijc.31797
ISSN: 0020-7136
Publisher: Wiley
Start Page: 2437
End Page: 2448
Journal / Book Title: International Journal of Cancer
Volume: 143
Issue: 10
Copyright Statement: © 2018 Owner. This is the accepted version of an article which has been published in final form at https://dx.doi.org/10.1002/ijc.31797
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
biomarkers
plasma phospholipids
fatty acids
tobacco smoking
pancreatic cancer
OVARIAN-CANCER
FOOD-INTAKE
F344 RATS
NUTRITION
DIET
ASSOCIATIONS
INDUCTION
CARCINOMA
HEALTH
GROWTH
biomarkers
fatty acids
pancreatic cancer
plasma phospholipids
tobacco smoking
Adult
Aged
Case-Control Studies
Cohort Studies
Europe
Fatty Acids
Female
Humans
Incidence
Male
Middle Aged
Pancreatic Neoplasms
Phospholipids
Risk
Humans
Pancreatic Neoplasms
Fatty Acids
Phospholipids
Incidence
Risk
Case-Control Studies
Cohort Studies
Adult
Aged
Middle Aged
Europe
Female
Male
biomarkers
fatty acids
pancreatic cancer
plasma phospholipids
tobacco smoking
1112 Oncology and Carcinogenesis
Oncology & Carcinogenesis
Publication Status: Published
Conference Place: United States
Online Publication Date: 2018-08-15
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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