Helminth lifespan interacts with noncompliance in reducing the effectiveness of anthelmintic treatment

Title: Helminth lifespan interacts with noncompliance in reducing the effectiveness of anthelmintic treatment
Author(s): Farrell, SH
Anderson, RM
Item Type: Journal Article
Abstract: Background The success of mass drug administration programmes targeting the soil-transmitted helminths and schistosome parasites is in part dependent on compliance to treatment at sequential rounds of mass drug administration (MDA). The impact of MDA is vulnerable to systematic non-compliance, defined as a portion of the eligible population remaining untreated over successive treatment rounds. The impact of systematic non-compliance on helminth transmission dynamics - and thereby on the number of treatment rounds required to interrupt transmission - is dependent on the parasitic helminth being targeted by MDA. Results Here, we investigate the impact of adult parasite lifespan in the human host and other factors that determine the magnitude of the basic reproductive number R 0 , on the number of additional treatment rounds required in a target population, using mathematical models of Ascaris lumbricoides and Schistosoma mansoni transmission incorporating systematic non-compliance. Our analysis indicates a strong interaction between helminth lifespan and the impact of systematic non-compliance on parasite elimination, and confirms differences in its impact between Ascaris and the schistosome parasites in a streamlined model structure. Conclusions Our analysis suggests that achieving reductions in the level of systematic non-compliance may be of particular benefit in mass drug administration programmes treating the longer-lived helminth parasites, and highlights the need for improved data collection in understanding the impact of compliance.
Publication Date: 31-Jan-2018
Date of Acceptance: 23-Jan-2018
URI: http://hdl.handle.net/10044/1/62087
DOI: https://dx.doi.org/10.1186/s13071-018-2670-6
ISSN: 1756-3305
Publisher: BIOMED CENTRAL LTD
Journal / Book Title: PARASITES & VECTORS
Volume: 11
Copyright Statement: © 2018 The Author(s). Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ ) applies to the data made available in this article, unless otherwise stated.
Keywords: Science & Technology
Life Sciences & Biomedicine
Parasitology
Tropical Medicine
Soil-transmitted helminths
Schistosomiasis
Mass drug administration
Compliance
Systematic noncompliance
Mathematical modelling
Elimination
Transmission interruption
WUCHERERIA-BANCROFTI INFECTION
SOIL-TRANSMITTED HELMINTHS
MASS
TRANSMISSION
ELIMINATION
CHEMOTHERAPY
DYNAMICS
IMPACT
Compliance
Elimination
Mass drug administration
Mathematical modelling
Schistosomiasis
Soil-transmitted helminths
Systematic non-compliance
Transmission interruption
Science & Technology
Life Sciences & Biomedicine
Parasitology
Tropical Medicine
Soil-transmitted helminths
Schistosomiasis
Mass drug administration
Compliance
Systematic noncompliance
Mathematical modelling
Elimination
Transmission interruption
WUCHERERIA-BANCROFTI INFECTION
SOIL-TRANSMITTED HELMINTHS
MASS
TRANSMISSION
ELIMINATION
CHEMOTHERAPY
DYNAMICS
IMPACT
1108 Medical Microbiology
1117 Public Health And Health Services
Mycology & Parasitology
Tropical Medicine
Publication Status: Published
Article Number: ARTN 66
Online Publication Date: 2018-01-31
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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