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Traumatic brain injury impairs small-world topology

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Title: Traumatic brain injury impairs small-world topology
Authors: Pandit, AS
Expert, P
Lambiotte, R
Bonnelle, V
Leech, R
Turkheimer, FE
Sharp, DJ
Item Type: Journal Article
Abstract: Objective: We test the hypothesis that brain networks associated with cognitive function shift away from a “small-world” organization following traumatic brain injury (TBI). Methods: We investigated 20 TBI patients and 21 age-matched controls. Resting-state functional MRI was used to study functional connectivity. Graph theoretical analysis was then applied to partial correlation matrices derived from these data. The presence of white matter damage was quantified using diffusion tensor imaging. Results: Patients showed characteristic cognitive impairments as well as evidence of damage to white matter tracts. Compared to controls, the graph analysis showed reduced overall connectivity, longer average path lengths, and reduced network efficiency. A particular impact of TBI is seen on a major network hub, the posterior cingulate cortex. Taken together, these results confirm that a network critical to cognitive function shows a shift away from small-world characteristics. Conclusions: We provide evidence that key brain networks involved in supporting cognitive function become less small-world in their organization after TBI. This is likely to be the result of diffuse white matter damage, and may be an important factor in producing cognitive impairment after TBI.
Issue Date: 14-May-2013
Date of Acceptance: 18-Jan-2013
URI: http://hdl.handle.net/10044/1/62075
DOI: https://dx.doi.org/10.1212/WNL.0b013e3182929f38
ISSN: 0028-3878
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Start Page: 1826
End Page: 1833
Journal / Book Title: NEUROLOGY
Volume: 80
Issue: 20
Copyright Statement: © 2013 American Academy of Neurology.
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Medical Research Council (MRC)
National Institute for Health Research
Funder's Grant Number: EP/E049451/1
G0701951
NIHR-RP-011-048
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences & Neurology
DEFAULT MODE NETWORK
POSTERIOR CINGULATE CORTEX
AXONAL INJURY
STRUCTURAL CONNECTIVITY
HEAD-INJURY
STATE
PERFORMANCE
DISRUPTION
ATTENTION
RECOVERY
Adolescent
Adult
Brain Injuries
Brain Mapping
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net
Neuropsychological Tests
Young Adult
1103 Clinical Sciences
1109 Neurosciences
1702 Cognitive Science
Neurology & Neurosurgery
Publication Status: Published
Open Access location: http://n.neurology.org/content/80/20/1826.long
Online Publication Date: 2013-04-17
Appears in Collections:Mathematics
Department of Medicine
Applied Mathematics and Mathematical Physics
Faculty of Natural Sciences



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