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The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease

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Title: The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease
Authors: Chambers, E
Byrne, C
Rugyendo, A
Morrison, D
Preston, T
Tedford, C
Bell, J
Thomas, L
Akbar, A
Riddell, N
Sharma, R
Thursz, M
Manousou, P
Frost, G
Item Type: Journal Article
Abstract: The short chain fatty acid (SCFA) propionate, produced through fermentation of dietary fibre by the gut microbiota, has been shown to alter hepatic metabolic processes that reduce lipid storage. We aimed to investigate the impact of raising colonic propionate production on hepatic steatosis in adults with non‐alcoholic fatty liver disease (NAFLD). Eighteen adults were randomised to receive 20g/day of an inulin‐propionate ester (IPE), designed to deliver propionate to the colon, or an inulin‐control for 42‐days in a parallel design. The change in intrahepatocellular lipid (IHCL) following the supplementation period was not different between groups (P=0.082), however IHCL significantly increased within the inulin‐control group (20.9±2.9 to 26.8±3.9%; P=0.012; n=9), which was not observed within the IPE group (22.6±6.9 to 23.5±6.8%; P=0.635; n=9). The predominant SCFA from colonic fermentation of inulin is acetate, which in a background of NAFLD and a hepatic metabolic profile that promotes fat accretion, may provide surplus lipogenic substrate to the liver. The increased colonic delivery of propionate from IPE appears to attenuate this acetate‐mediated increase in IHCL.
Issue Date: 1-Aug-2019
Date of Acceptance: 7-Aug-2018
URI: http://hdl.handle.net/10044/1/61956
DOI: https://dx.doi.org/10.1111/dom.13500
ISSN: 1462-8902
Publisher: Wiley
Start Page: 372
End Page: 376
Journal / Book Title: Diabetes, Obesity and Metabolism
Volume: 21
Issue: 2
Copyright Statement: © 2018 Wiley. This is the accepted version of an article which has been published in final form at https://dx.doi.org/10.1111/dom.13500
Sponsor/Funder: Commission of the European Communities
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Council (BBSRC)
National Institute for Health Research
Funder's Grant Number: 289511
BB/H004971/1
BB/L004259/1
NF-SI-0513-10029
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
clinical trial
dietary intervention
fatty liver
insulin resistance
DE-NOVO LIPOGENESIS
APPETITE REGULATION
HIGH-CARBOHYDRATE
ACID
OLIGOFRUCTOSE
INDIVIDUALS
MAINTENANCE
METABOLISM
clinical trial
dietary intervention
fatty liver
insulin resistance
1103 Clinical Sciences
Endocrinology & Metabolism
Publication Status: Published
Online Publication Date: 2018-08-11
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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