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A semi-automatic technique to quantify complex tuberculous lung lesions on F-18-fluorodeoxyglucose positron emission tomography/computerised tomography images

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Title: A semi-automatic technique to quantify complex tuberculous lung lesions on F-18-fluorodeoxyglucose positron emission tomography/computerised tomography images
Authors: Malherbe, ST
Dupont, P
Kant, I
Ahlers, P
Kriel, M
Loxton, AG
Chen, RY
Via, LE
Thienemann, F
Wilkinson, RJ
Barry, CE
Griffith-Richards, S
Ellman, A
Ronacher, K
Winter, J
Walzl, G
Warwick, JM
Item Type: Journal Article
Abstract: Background There is a growing interest in the use of 18F-FDG PET-CT to monitor tuberculosis (TB) treatment response. However, TB causes complex and widespread pathology, which is challenging to segment and quantify in a reproducible manner. To address this, we developed a technique to standardise uptake (Z-score), segment and quantify tuberculous lung lesions on PET and CT concurrently, in order to track changes over time. We used open source tools and created a MATLAB script. The technique was optimised on a training set of five pulmonary tuberculosis (PTB) cases after standard TB therapy and 15 control patients with lesion-free lungs. Results We compared the proposed method to a fixed threshold (SUV > 1) and manual segmentation by two readers and piloted the technique successfully on scans of five control patients and five PTB cases (four cured and one failed treatment case), at diagnosis and after 1 and 6 months of treatment. There was a better correlation between the Z-score-based segmentation and manual segmentation than SUV > 1 and manual segmentation in terms of overall spatial overlap (measured in Dice similarity coefficient) and specificity (1 minus false positive volume fraction). However, SUV > 1 segmentation appeared more sensitive. Both the Z-score and SUV > 1 showed very low variability when measuring change over time. In addition, total glycolytic activity, calculated using segmentation by Z-score and lesion-to-background ratio, correlated well with traditional total glycolytic activity calculations. The technique quantified various PET and CT parameters, including the total glycolytic activity index, metabolic lesion volume, lesion volumes at different CT densities and combined PET and CT parameters. The quantified metrics showed a marked decrease in the cured cases, with changes already apparent at month one, but remained largely unchanged in the failed treatment case. Conclusions Our technique is promising to segment and quantify the lung scans of pulmonary tuberculosis patients in a semi-automatic manner, appropriate for measuring treatment response. Further validation is required in larger cohorts.
Issue Date: 25-Jun-2018
Date of Acceptance: 8-Jun-2018
URI: http://hdl.handle.net/10044/1/61935
DOI: https://dx.doi.org/10.1186/s13550-018-0411-7
ISSN: 2191-219X
Publisher: Springer
Journal / Book Title: EJNMMI Research
Volume: 8
Copyright Statement: © The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
Keywords: Science & Technology
Life Sciences & Biomedicine
Radiology, Nuclear Medicine & Medical Imaging
F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography
Tuberculosis
Image analysis
Lesion segmentation
Lesion quantification
COMPUTED-TOMOGRAPHY
PET-CT
THERAPEUTIC RESPONSE
HODGKIN LYMPHOMA
MESSENGER-RNA
TUMOR VOLUME
FDG-PET/CT
F-18-FDG
SEGMENTATION
QUANTIFICATION
18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography
Catalysis Biomarker Consortium
Publication Status: Published
Open Access location: https://ejnmmires.springeropen.com/track/pdf/10.1186/s13550-018-0411-7
Article Number: ARTN 55
Appears in Collections:Department of Medicine



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