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Use of Laser Speckle Contrast Analysis during pelvic surgery in a uterine transplantation model

Title: Use of Laser Speckle Contrast Analysis during pelvic surgery in a uterine transplantation model
Authors: Saso, S
Tziraki, M
Clancy, NT
Song, L
Bracewell-Milnes, T
Jones, BP
Al-Memar, M
Yazbek, J
Thum, M-Y
Sayasneh, A
Bourne, T
Smith, JR
Elson, DS
Ghaem-Maghami, S
Item Type: Journal Article
Abstract: Aim: Uterine transplantation (UTx) is proposed for treatment of uterine factor infertility. Our aim was to assess whether Endoscopic Laser Speckle Contrast Analysis (eLASCA) could evaluate pelvic blood flow at anastomotic sites required for sheep and rabbit UTx. Results/methodology: eLASCA detected blood flow in rabbit UTx #7 and #9. In sheep UTx #2, #3 and #5, the results allowed us to conclude that blood flow was present in the uterine graft following transplantation; and post-UTx, the animal had heart and respiratory rates, and oxygen saturation compatible with a normal hemodynamic status. Conclusion: These preliminary results establish the potential of Laser Speckle Contrast Analysis as noncontact and real-time tool for observation of spatially-resolved blood flow from which other parameters can be derived.
Issue Date: 1-Aug-2018
Date of Acceptance: 4-Jun-2018
URI: http://hdl.handle.net/10044/1/61843
DOI: https://dx.doi.org/10.4155/fsoa-2018-0017
ISSN: 2056-5623
Publisher: Future Science
Start Page: FSO324
End Page: FSO324
Journal / Book Title: Future Science OA
Volume: 4
Issue: 7
Copyright Statement: © 2018 Srdjan Saso. This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Commission of the European Communities
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Cancer Research UK
Funder's Grant Number: 242991
RDB04 79560
RD207
C24523/A25147
Keywords: graft anastomosis
oxygen saturation
surgical imaging
tissue perfusion
uterine transplantation
Publication Status: Published
Conference Place: England
Appears in Collections:Division of Surgery
Faculty of Medicine



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