Nontuberculous mycobacterial disease managed within UK primary care, 2006-2016

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Title: Nontuberculous mycobacterial disease managed within UK primary care, 2006-2016
Authors: Axson, EL
Bloom, CI
Quint, JK
Item Type: Journal Article
Abstract: Previous UK studies investigating nontuberculous mycobacteria have been limited to reporting isolation from culture, not burden of disease. We assessed the burden of nontuberculous mycobacterial disease (NTMD) in UK primary care from 2006 to 2016. Using electronic healthcare records, we identified patients with NTMD using a strict definition including patients with guideline-directed treatment/monitoring. We described treatment regimens and incidence/prevalence in the general population and in patients with underlying chronic respiratory diseases. Incidence of primary care-managed NTMD in the general population decreased (2006 to 2016 rates per 100,000 person-years, 3.85 to 1.28). Average annual prevalence of NTMD in the general population was 6.38 per 100,000. Around 85% were taking antimycobacterial therapy; 53.2% were taking a guideline-recommended regimen. Incidence of NTMD in patients with respiratory disease decreased (2006 to 2016 rates per 100,000 person-years, 12.5 to 7.40). Average annual prevalence of NTMD in patients with respiratory disease was 27.7 per 100,000. This is the first UK study using nationally representative data to investigate the burden of NTMD managed within primary care. Incidence and prevalence of managed NTMD within primary care is gradually declining. Increasing complexity in the management of NTMD may be driving a shift in care to secondary settings.
Issue Date: 1-Sep-2018
Date of Acceptance: 21-Jun-2018
URI: http://hdl.handle.net/10044/1/61689
DOI: https://doi.org/10.1007/s10096-018-3315-6
ISSN: 0934-9723
Publisher: Springer Verlag
Start Page: 1795
End Page: 1803
Journal / Book Title: European Journal of Clinical Microbiology and Infectious Diseases
Volume: 37
Issue: 9
Copyright Statement: © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Sponsor/Funder: Insmed Limited
Funder's Grant Number: n/a
Keywords: Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
Microbiology
Epidemiology
Primary care
NTM
COPD
Bronchiectasis
EPIDEMIOLOGY
PREVALENCE
INFECTIONS
RISK
Bronchiectasis
COPD
Epidemiology
NTM
Primary care
Adolescent
Aged
Anti-Bacterial Agents
Bronchiectasis
Cost of Illness
Disease Management
Electronic Health Records
Female
Humans
Incidence
Male
Middle Aged
Mycobacterium Infections, Nontuberculous
Nontuberculous Mycobacteria
Prevalence
Primary Health Care
Pulmonary Disease, Chronic Obstructive
United Kingdom
Young Adult
Humans
Bronchiectasis
Pulmonary Disease, Chronic Obstructive
Anti-Bacterial Agents
Incidence
Prevalence
Cost of Illness
Adolescent
Aged
Middle Aged
Primary Health Care
Disease Management
Female
Male
Young Adult
Electronic Health Records
Mycobacterium Infections, Nontuberculous
Nontuberculous Mycobacteria
United Kingdom
06 Biological Sciences
11 Medical and Health Sciences
Microbiology
Publication Status: Published
Online Publication Date: 2018-06-27
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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