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Positron emission tomography studies of the Glial cell marker translocator protein in patients with psychosis: a meta-analysis using individual participant data

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Title: Positron emission tomography studies of the Glial cell marker translocator protein in patients with psychosis: a meta-analysis using individual participant data
Authors: Plavén-Sigray, P
Matheson, GJ
Collste, K
Ashok, AH
Coughlin, JM
Howes, OD
Mizrahi, R
Pomper, MG
Rusjan, P
Veronese, M
Wang, Y
Cervenka, S
Item Type: Journal Article
Abstract: BACKGROUND: Accumulating evidence suggests that the immune system may be an important target for new treatment approaches in schizophrenia. Positron emission tomography and radioligands binding to the translocator protein (TSPO), which is expressed in glial cells in the brain including immune cells, represents a potential method for patient stratification and treatment monitoring. This study examined whether patients with first-episode psychosis and schizophrenia had altered TSPO levels compared with healthy control subjects. METHODS: PubMed was searched for studies comparing patients with psychosis with healthy control subjects using second-generation TSPO radioligands. The outcome measure was total distribution volume (VT), an index of TSPO levels, in frontal cortex, temporal cortex, and hippocampus. Bayes factors (BFs) were applied to examine the relative support for higher, lower, or no difference in patients' TSPO levels compared with healthy control subjects. RESULTS: Five studies, with 75 participants with first-episode psychosis or schizophrenia and 77 healthy control subjects, were included. BFs showed strong support for lower VT in patients relative to no difference (all BFs > 32), or relative to higher VT (all BFs > 422), in all brain regions. From the posterior distributions, mean patient-control differences in standardized VT values were -0.48 for frontal cortex (95% credible interval [CredInt] = -0.88 to 0.09), -0.47 for temporal cortex (CredInt = -0.87 to -0.07), and -0.63 for hippocampus (CredInt = -1.00 to -0.25). CONCLUSIONS: The lower levels of TSPO observed in patients may correspond to altered function or lower density of brain immune cells. Future studies should focus on investigating the underlying biological mechanisms and their relevance for treatment.
Issue Date: 1-Sep-2018
Date of Acceptance: 20-Feb-2018
URI: http://hdl.handle.net/10044/1/61665
DOI: https://dx.doi.org/10.1016/j.biopsych.2018.02.1171
ISSN: 0006-3223
Publisher: Elsevier
Start Page: 433
End Page: 442
Journal / Book Title: Biological Psychiatry
Volume: 84
Copyright Statement: © 2018 Society of Biological Psychiatry. Published by Elsevier Inc. This is an open access article under theCC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 607616
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Psychiatry
Neurosciences & Neurology
Immune activation
Meta-analysis
Microglia
Positron emission tomography
Psychosis
Schizophrenia
Translocator protein
BENZODIAZEPINE-RECEPTOR LIGAND
IMAGING MICROGLIAL ACTIVATION
PLACEBO-CONTROLLED TRIAL
IN-VIVO PET
18 KDA
HUMAN-BRAIN
CELECOXIB AUGMENTATION
1ST-EPISODE PSYCHOSIS
WHITE-MATTER
DOUBLE-BLIND
Immune activation
Meta-analysis
Microglia
Positron emission tomography
Psychosis
Schizophrenia
Translocator protein
Immune activation
Meta-analysis
Microglia
Positron emission tomography
Psychosis
Schizophrenia
Translocator protein
Psychiatry
06 Biological Sciences
17 Psychology and Cognitive Sciences
11 Medical and Health Sciences
Publication Status: Published
Conference Place: United States
Open Access location: http://10.0.3.248/j.biopsych.2018.02.1171
Online Publication Date: 2018-03-06
Appears in Collections:Clinical Sciences
Imaging Sciences
Faculty of Medicine



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