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On-probe neural interface ASIC for combined electrical recording and optogenetic stimulation

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Title: On-probe neural interface ASIC for combined electrical recording and optogenetic stimulation
Authors: Ramezani, R
Liu, Y
Dehkhoda, F
Soltan, A
Haci, D
Zhao, H
Hazra, A
Cunningham, M
Firfilionis, D
Jackson, A
Constandinou, TG
Degenaar, P
Item Type: Journal Article
Abstract: Neuromodulation technologies are progressing from pacemaking and sensory operations to full closed-loop control. In particular, optogenetics—the genetic modification of light sensitivity into neural tissue allows for simultaneous optical stimulation and electronic recording. This paper presents a neural interface application-specified integrated circuit (ASIC) for intelligent optoelectronic probes. The architecture is designed to enable simultaneous optical neural stimulation and electronic recording. It provides four low noise (2.08 μVrms) recording channels optimized for recording local field potentials (LFPs) (0.1–300 Hz bandwidth, ± 5 mV range, sampled 10-bit@4 kHz), which are more stable for chronic applications. For stimulation, it provides six independently addressable optical driver circuits, which can provide both intensity (8-bit resolution across a 1.1 mA range) and pulse-width modulation for high-radiance light emitting diodes (LEDs). The system includes a fully digital interface using a serial peripheral interface (SPI) protocol to allow for use with embedded controllers. The SPI interface is embedded within a finite state machine (FSM), which implements a command interpreter that can send out LFP data whilst receiving instructions to control LED emission. The circuit has been implemented in a commercially available 0.35 μm CMOS technology occupying a 1.95 mm × 1.10 mm footprint for mounting onto the head of a silicon probe. Measured results are given for a variety of bench-top, in vitro and in vivo experiments, quantifying system performance and also demonstrating concurrent recording and stimulation within relevant experimental models.
Issue Date: 1-Jun-2018
Date of Acceptance: 15-May-2018
URI: http://hdl.handle.net/10044/1/61627
DOI: https://dx.doi.org/10.1109/TBCAS.2018.2818818
ISSN: 1932-4545
Publisher: Institute of Electrical and Electronics Engineers
Start Page: 576
End Page: 588
Journal / Book Title: IEEE Transactions on Biomedical Circuits and Systems
Volume: 12
Issue: 3
Copyright Statement: © 2018 IEEE. Translations and content mining are permitted for academic research only. Personal use is also permitted, but republication/ redistribution requires IEEE permission. See http://www.ieee.org/publications standards/publications/rights/index.html for more information
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: BH134389
Keywords: Science & Technology
Technology
Engineering, Biomedical
Engineering, Electrical & Electronic
Engineering
Channelrhodopsin
implantable
neural interface
neural recording
optoelectrode
optogenetics
optrode
NEURONS IN-VIVO
FIELD POTENTIALS
CLOSED-LOOP
AMPLIFIER
CHANNELRHODOPSIN-2
ARRAY
DESIGN
SYSTEM
SOC
0903 Biomedical Engineering
0906 Electrical And Electronic Engineering
Electrical & Electronic Engineering
Publication Status: Published
Online Publication Date: 2018-05-15
Appears in Collections:Electrical and Electronic Engineering



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