Motion-corrected multiparametric renal arterial spin labelling at 3T: Reproducibility and effect of vasodilator challenge

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Title: Motion-corrected multiparametric renal arterial spin labelling at 3T: Reproducibility and effect of vasodilator challenge
Authors: Shirvani, S
Tokarczuk, P
Statton, B
Quinlan, M
Berry, A
Tomlinson, J
Weale, P
Kuhn, B
O'Regan, DP
Item Type: Journal Article
Abstract: Objectives We investigated the feasibility and reproducibility of free-breathing motion-corrected multiple inversion time (multi-TI) pulsed renal arterial spin labelling (PASL), with general kinetic model parametric mapping, to simultaneously quantify renal perfusion (RBF), bolus arrival time (BAT) and tissue T1. Methods In a study approved by the Health Research Authority, 12 healthy volunteers (mean age, 27.6 ± 18.5 years; 5 male) gave informed consent for renal imaging at 3 T using multi-TI ASL and conventional single-TI ASL. Glyceryl trinitrate (GTN) was used as a vasodilator challenge in six subjects. Flow-sensitive alternating inversion recovery (FAIR) preparation was used with background suppression and 3D-GRASE (gradient and spin echo) read-out, and images were motion-corrected. Parametric maps of RBF, BAT and T1 were derived for both kidneys. Agreement was assessed using Pearson correlation and Bland-Altman plots. Results Inter-study correlation of whole-kidney RBF was good for both single-TI (r2 = 0.90), and multi-TI ASL (r2 = 0.92). Single-TI ASL gave a higher estimate of whole-kidney RBF compared to multi-TI ASL (mean bias, 29.3 ml/min/100 g; p <0.001). Using multi-TI ASL, the median T1 of renal cortex was shorter than that of medulla (799.6 ms vs 807.1 ms, p = 0.01), and mean whole-kidney BAT was 269.7 ± 56.5 ms. GTN had an effect on systolic blood pressure (p < 0.05) but the change in RBF was not significant. Conclusions Free-breathing multi-TI renal ASL is feasible and reproducible at 3 T, providing simultaneous measurement of renal perfusion, haemodynamic parameters and tissue characteristics at baseline and during pharmacological challenge.
Issue Date: Jan-2019
Date of Acceptance: 22-Jun-2018
URI: http://hdl.handle.net/10044/1/61596
DOI: https://doi.org/10.1007/s00330-018-5628-3
ISSN: 0938-7994
Publisher: Springer Verlag
Start Page: 232
End Page: 240
Journal / Book Title: European Radiology
Volume: 29
Issue: 1
Copyright Statement: © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
Medical Research Council (MRC)
Funder's Grant Number: RDC04
PO#4050724483
Keywords: Science & Technology
Life Sciences & Biomedicine
Radiology, Nuclear Medicine & Medical Imaging
Blood flow velocity
Computer-assisted image processing
Magnetic resonance imaging
Renal circulation
Vasodilator agents
BLOOD-FLOW
CORTICOMEDULLARY DIFFERENTIATION
NONINVASIVE MEASUREMENT
PERFUSION
ASL
QUANTIFICATION
MRI
AUTOREGULATION
HEALTH
TIME
Blood flow velocity
Computer-assisted image processing
Magnetic resonance imaging
Renal circulation
Vasodilator agents
Adult
Female
Healthy Volunteers
Humans
Kidney
Magnetic Resonance Imaging
Male
Prospective Studies
Renal Artery
Reproducibility of Results
Spin Labels
Vasodilation
Vasodilator Agents
Kidney
Renal Artery
Humans
Spin Labels
Vasodilator Agents
Magnetic Resonance Imaging
Prospective Studies
Reproducibility of Results
Vasodilation
Adult
Female
Male
Healthy Volunteers
1103 Clinical Sciences
Nuclear Medicine & Medical Imaging
Publication Status: Published
Online Publication Date: 2018-07-10
Appears in Collections:Clinical Sciences
Imaging Sciences
Faculty of Medicine



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