3D velocity and volume flow measurement in vivo using speckle decorrelation and 2D high frame rate contrast-enhanced ultrasound

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Title: 3D velocity and volume flow measurement in vivo using speckle decorrelation and 2D high frame rate contrast-enhanced ultrasound
Authors: Zhou, X
Leow, CH
Rowland, E
Riemer, K
Rubin, J
Weinberg, P
Tang, M
Item Type: Journal Article
Abstract: Being able to measure 3D flow velocity and volumetric flow rate effectively in the cardiovascular system is valuable but remains a significant challenge in both clinical practice and research. Currently there has not been an effective and practical solution to the measurement of volume flow using ultrasound imaging systems due to challenges in existing 3D imaging techniques and high system cost. In this study, a new technique for quantifying volumetric flow rate from the cross-sectional imaging plane of the blood vessel was developed by using speckle decorrelation, 2D high frame rate imaging with a standard 1D array transducer, microbubble contrast agents, and ultrasound imaging velocimetry (UIV). Through speckle decorrelation analysis of microbubble signals acquired with a very high frame rate and by using UIV to estimate the two in-plane flow velocity components, the third and out-of-plane velocity component can be obtained over time and integrated to estimate volume flow. The proposed technique was evaluated on a wall-less flow phantom in both steady and pulsatile flow. UIV in the longitudinal direction was conducted as a reference. The influences of frame rate, mechanical index, orientation of imaging plane, and compounding on velocity estimation were also studied. In addition, an in vivo trial on the abdominal aorta of a rabbit was conducted. The results show that the new system can estimate volume flow with an averaged error of 3.65±2.37% at a flow rate of 360 ml/min and a peak velocity of 0.45 m/s, and an error of 5.03±2.73% at a flow rate of 723 ml/min and a peak velocity of 0.8 m/s. The accuracy of the flow velocity and volumetric flow rate estimation directly depend on the imaging frame rate. With a frame rate of 6000 Hz, a velocity up to 0.8 m/s can be correctly estimated. A higher mechanical index (MI=0.42) is shown to produce greater errors (up to 21.78±0.49%, compared to 3.65±2.37% at MI=0.19). An in vivo trial, where velocities up to 1 m/s were correctly measured, demonstrated the potential of the technique in clinical applications.
Issue Date: 27-Jun-2018
Date of Acceptance: 15-Jun-2018
URI: http://hdl.handle.net/10044/1/61499
DOI: https://dx.doi.org/10.1109/TUFFC.2018.2850535
ISSN: 0885-3010
Publisher: Institute of Electrical and Electronics Engineers
Journal / Book Title: IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
Copyright Statement: The accepted manuscript is available open access. This work is licensed under a Creative Commons Attribution 3.0 License. For more information, see http://creativecommons.org/licenses/by/3.0/.
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
British Heart Foundation
Funder's Grant Number: EP/M011933/1
PG/16/95/32350
Keywords: 02 Physical Sciences
09 Engineering
Acoustics
Publication Status: Published online
Online Publication Date: 2018-06-27
Appears in Collections:Faculty of Engineering
Bioengineering



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