Cubosomes: the next generation of smart lipid nanoparticles?

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Title: Cubosomes: the next generation of smart lipid nanoparticles?
Authors: Barriga, HMG
Holme, MN
Stevens, MM
Item Type: Journal Article
Abstract: Cubosomes are highly stable nanoparticles formed from the lipid cubic phase and stabilized by a polymer based outer corona. Lipid cubic phases consist of a single lipid bilayer which forms a continuous periodic membrane lattice structure with pores formed by two interwoven water channels. Cubosome composition can be tuned to engineer pore sizes or include bioactive lipids, the polymer outer corona can be used for targeting and they are highly stable under physiological conditions. The structure provides a significantly higher membrane surface area for loading of membrane proteins and small drug molecules than liposomes. Due to recent advances, they can be engineered in vitro in both bulk and nanoparticle formats with applications including drug delivery, membrane bioreactors, artificial cells and biosensors. This review outlines recent advances in cubosome technology enabling their application and provides guidelines for the rational design of new systems for biomedical applications.
Issue Date: 4-Mar-2019
Date of Acceptance: 13-Jun-2018
URI: http://hdl.handle.net/10044/1/61459
DOI: https://doi.org/10.1002/anie.201804067
ISSN: 1521-3757
Publisher: Wiley
Start Page: 2958
End Page: 2978
Journal / Book Title: Angewandte Chemie
Volume: 58
Issue: 10
Copyright Statement: © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. . This is the accepted version of the following article, which has been published in final form at https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201804067
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Commission of the European Communities
Engineering & Physical Science Research Council (E
Engineering & Physical Science Research Council (EPSRC)
Commission of the European Communities
Funder's Grant Number: EP/K020641/1
ERC-2013-CoG-616417
EP/K031953/1
EP/J017566/1
PIEF-GA-2013-626766
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
cubosomes
drug delivery
lipids
nanoparticles
self-assembly
LIQUID-CRYSTALLINE NANOPARTICLES
CUBIC-PHASE
DRUG-DELIVERY
ANTIMICROBIAL PEPTIDES
INTERNAL STRUCTURE
GLYCEROL DIOLEATE
SUSTAINED-RELEASE
IN-VITRO
EX-VIVO
CYTOTOXICITY
cubosomes
drug delivery
lipids
nanoparticles
self-assembly
Organic Chemistry
03 Chemical Sciences
Publication Status: Published
Online Publication Date: 2018-06-21
Appears in Collections:Faculty of Engineering
Materials
Faculty of Natural Sciences



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