Overcoming the blood–brain barrier: the role of nanomaterials in treating neurological diseases

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Title: Overcoming the blood–brain barrier: the role of nanomaterials in treating neurological diseases
Author(s): Furtado, D
Bjornmalm, AMH
Ayton, S
Bush, A
Kempe, K
Caruso, F
Item Type: Journal Article
Abstract: Therapies directed toward the central nervous system remain difficult to translate into improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably the most tightly regulated interface in the human body, which routinely excludes most therapeutics. Advances in the engineering of nanomaterials and their application in biomedicine (i.e., nanomedicine) are enabling new strategies that have the potential to help improve our understanding and treatment of neurological diseases. Herein, the various mechanisms by which therapeutics can be delivered to the brain are examined and key challenges facing translation of this research from benchtop to bedside are highlighted. Following a contextual overview of the BBB anatomy and physiology in both healthy and diseased states, relevant therapeutic strategies for bypassing and crossing the BBB are discussed. The focus here is especially on nanomaterial‐based drug delivery systems and the potential of these to overcome the biological challenges imposed by the BBB. Finally, disease‐targeting strategies and clearance mechanisms are explored. The objective is to provide the diverse range of researchers active in the field (e.g., material scientists, chemists, engineers, neuroscientists, and clinicians) with an easily accessible guide to the key opportunities and challenges currently facing the nanomaterial‐mediated treatment of neurological diseases.
Publication Date: 31-Jul-2018
Date of Acceptance: 13-Apr-2018
URI: http://hdl.handle.net/10044/1/61427
DOI: https://dx.doi.org/10.1002/adma.201801362
ISSN: 0935-9648
Publisher: Wiley
Journal / Book Title: Advanced Materials
Sponsor/Funder: European Commission
Funder's Grant Number: 745676
Copyright Statement: © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the pre-peer reviewed version of the following article, which has been published in final form at https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201801362
Keywords: 02 Physical Sciences
03 Chemical Sciences
09 Engineering
Nanoscience & Nanotechnology
Publication Status: Published online
Embargo Date: 2019-07-31
Online Publication Date: 2018-07-31
Appears in Collections:Faculty of Engineering
Materials



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