Computed tomographic biomarkers in idiopathic pulmonary fibrosis: the future of quantitative analysis

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Title: Computed tomographic biomarkers in idiopathic pulmonary fibrosis: the future of quantitative analysis
Authors: Wu, X
Kim, GH
Salisbury, ML
Barber, D
Bartholmai, BJ
Brown, KK
Conoscenti, CS
De Backer, J
Flaherty, KR
Gruden, JF
Hoffman, EA
Humphries, SM
Jacob, J
Maher, TM
Raghu, G
Richeldi, L
Ross, BD
Schlenker-Herceg, R
Sverzellati, N
Wells, AU
Martinez, FJ
Lynch, DA
Goldin, J
Walsh, SLF
Item Type: Journal Article
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with great variability in disease severity and rate of progression. The need for a reliable, sensitive, and objective biomarker to track disease progression and response to therapy remains a great challenge in IPF clinical trials. Over the past decade, quantitative computed tomography (QCT) has emerged as an area of intensive research to address this need. We have gathered a group of pulmonologists, radiologists and scientists with expertise in this area to define the current status and future promise of this imaging technique in the evaluation and management of IPF. In this Pulmonary Perspective, we review the development and validation of six computer-based QCT methods and offer insight into the optimal use of an imaging-based biomarker as a tool for prognostication, prediction of response to therapy, and potential surrogate endpoint in future therapeutic trials.
Issue Date: 1-Jan-2019
Date of Acceptance: 6-Jul-2018
URI: http://hdl.handle.net/10044/1/61127
DOI: https://doi.org/10.1164/rccm.201803-0444PP
ISSN: 1073-449X
Publisher: American Thoracic Society
Start Page: 12
End Page: 21
Journal / Book Title: American Journal of Respiratory and Critical Care Medicine
Volume: 199
Issue: 1
Copyright Statement: © 2018 by the American Thoracic Society.
Keywords: Science & Technology
Life Sciences & Biomedicine
Critical Care Medicine
Respiratory System
General & Internal Medicine
INTERSTITIAL LUNG-DISEASE
HIGH-RESOLUTION CT
FORCED VITAL CAPACITY
END-POINTS
HYPERSENSITIVITY PNEUMONITIS
AUTOMATED QUANTIFICATION
IMAGING BIOMARKERS
TREATMENT TRIALS
CLINICAL-TRIALS
STAGING SYSTEM
biomarker
idiopathic pulmonary fibrosis
quantitative computed tomography
11 Medical and Health Sciences
Respiratory System
Publication Status: Published
Conference Place: United States
Online Publication Date: 2018-07-09
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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