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Pirfenidone in idiopathic pulmonary fibrosis: expert panel discussion on the management of drug-related adverse events

Title: Pirfenidone in idiopathic pulmonary fibrosis: expert panel discussion on the management of drug-related adverse events
Authors: Costabel, U
Bendstrup, E
Cottin, V
Dewint, P
Egan, JJJ
Ferguson, J
Groves, R
Hellström, PM
Kreuter, M
Maher, TM
Molina-Molina, M
Nordlind, K
Sarafidis, A
Vancheri, C
Item Type: Journal Article
Abstract: Pirfenidone is currently the only approved therapy for idiopathic pulmonary fibrosis, following studies demonstrating that treatment reduces the decline in lung function and improves progression-free survival. Although generally well tolerated, a minority of patients discontinue therapy due to gastrointestinal and skin-related adverse events (AEs). This review summarizes recommendations based on existing guidelines, research evidence, and consensus opinions of expert authors, with the aim of providing practicing physicians with the specific clinical information needed to educate the patient and better manage pirfenidone-related AEs with continued pirfenidone treatment. The main recommendations to help prevent and/or mitigate gastrointestinal and skin-related AEs include taking pirfenidone during (or after) a meal, avoiding sun exposure, wearing protective clothing, and applying a broad-spectrum sunscreen with high ultraviolet (UV) A and UVB protection. These measures can help optimize AE management, which is key to maintaining patients on an optimal treatment dose.
Issue Date: 1-Jan-2014
Date of Acceptance: 1-Mar-2014
URI: http://hdl.handle.net/10044/1/61080
DOI: https://dx.doi.org/10.1007/s12325-014-0112-1
ISSN: 0741-238X
Publisher: Springer Verlag
Start Page: 375
End Page: 391
Journal / Book Title: Advances in Therapy
Volume: 31
Issue: 4
Copyright Statement: © 2014 The Author(s). This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Keywords: Anti-Inflammatory Agents, Non-Steroidal
Disease Management
Disease-Free Survival
Drug-Related Side Effects and Adverse Reactions
Humans
Idiopathic Pulmonary Fibrosis
Pyridones
Respiratory Function Tests
Tumor Necrosis Factor-alpha
1115 Pharmacology And Pharmaceutical Sciences
General Clinical Medicine
Publication Status: Published
Conference Place: United States
Online Publication Date: 2014-03-18
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



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