Are We on Our Way to Achieving the 2020 Goals for Schistosomiasis Morbidity Control Using Current World Health Organization Guidelines?

Title: Are We on Our Way to Achieving the 2020 Goals for Schistosomiasis Morbidity Control Using Current World Health Organization Guidelines?
Author(s): Toor, J
Alsallaq, R
Truscott, JE
Turner, HC
Werkman, M
Gurarie, D
King, CH
Anderson, RM
Item Type: Journal Article
Abstract: Background Schistosomiasis remains an endemic parasitic disease affecting millions of people around the world. The World Health Organization (WHO) has set goals of controlling morbidity to be reached by 2020, along with elimination as a public health problem in certain regions by 2025. Mathematical models of parasite transmission and treatment impact have been developed to assist in controlling the morbidity caused by schistosomiasis. These models can inform and guide implementation policy for mass drug administration programs, and help design monitoring and evaluation activities. Methods We use these models to predict whether the guidelines set by the WHO are on track for achieving their 2020 goal for the control of morbidity, specifically for Schistosoma mansoni. We examine whether programmatic adaptations; namely increases in treatment coverage and/or expansion to adult inclusion in treatment, will improve the likelihood of reaching the WHO goals. Results We find that in low-prevalence settings, the goals are likely to be attainable under current WHO guidelines, but in moderate to high-prevalence settings, the goals are less likely to be achieved unless treatment coverage is increased and expanded to at least 85% for school-aged children and 40% for adults. Conclusions To improve the likelihood of reaching the WHO goals, programmatic adaptations are required, particularly for moderate- to high-prevalence settings. Furthermore, improvements in adherence to treatment, potential development of candidate vaccines, and enhanced snail control and WASH (water, sanitation, and hygiene) measures will all assist in achieving the goals.
Publication Date: 15-Jun-2018
Date of Acceptance: 1-Jun-2018
URI: http://hdl.handle.net/10044/1/60733
DOI: https://dx.doi.org/10.1093/cid/ciy001
ISSN: 1058-4838
Publisher: OXFORD UNIV PRESS INC
Start Page: S245
End Page: S252
Journal / Book Title: CLINICAL INFECTIOUS DISEASES
Volume: 66
Issue: suppl_4
Copyright Statement: © 2018 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright Statement: © 2018 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Microbiology
Schistosomiasis
WHO guidelines
morbidity control
elimination as a public health problem
POPULATION-DYNAMICS
TRANSMISSION
PREVALENCE
MANSONI
COST
Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Microbiology
Schistosomiasis
WHO guidelines
morbidity control
elimination as a public health problem
POPULATION-DYNAMICS
TRANSMISSION
PREVALENCE
MANSONI
COST
06 Biological Sciences
11 Medical And Health Sciences
Microbiology
Publication Status: Published
Online Publication Date: 2018-06-01
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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