Pre-diagnostic polyphenol intake and breast cancer survival: the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

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Title: Pre-diagnostic polyphenol intake and breast cancer survival: the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Author(s): Kyro, C
Zamora-Ros, R
Scalbert, A
Tjonneland, A
Dossus, L
Johansen, C
Bidstrup, PE
Weiderpass, E
Christensen, J
Ward, H
Aune, D
Riboli, E
His, M
Clavel-Chapelon, F
Baglietto, L
Katzke, V
Kuehn, T
Boeing, H
Floegel, A
Overvad, K
Lasheras, C
Travier, N
Sanchez, M-J
Amiano, P
Chirlaque, M-D
Ardanaz, E
Khaw, K-T
Wareham, N
Perez-Cornago, A
Trichopoulou, A
Lagiou, P
Vasilopoulou, E
Masala, G
Grioni, S
Berrino, F
Tumino, R
Sacerdote, C
Mattiello, A
Bueno-de-Mesquita, HBA
Peeters, PH
Van Gils, C
Borgquist, S
Butt, S
Zeleniuch-Jacquotte, A
Sund, M
Hjartaker, A
Skeie, G
Olsen, A
Romieu, I
Item Type: Journal Article
Abstract: The aim was to investigate the association between pre-diagnostic intakes of polyphenol classes (flavonoids, lignans, phenolic acids, stilbenes, and other polyphenols) in relation to breast cancer survival (all-cause and breast cancer-specific mortality). We used data from the European Prospective Investigation into Cancer and Nutrition cohort. Pre-diagnostic usual diet was assessed using dietary questionnaires, and polyphenol intakes were estimated using the Phenol-Explorer database. We followed 11,782 breast cancer cases from time of diagnosis until death, end of follow-up or last day of contact. During a median of 6 years, 1482 women died (753 of breast cancer). We related polyphenol intake to all-cause and breast cancer-specific mortality using Cox proportional hazard models with time since diagnosis as underlying time and strata for age and country. Among postmenopausal women, an intake of lignans in the highest versus lowest quartile was related to a 28 % lower risk of dying from breast (adjusted model: HR, quartile 4 vs. quartile 1, 0.72, 95 % CI 0.53; 0.98). In contrast, in premenopausal women, a positive association between lignan intake and all-cause mortality was found (adjusted model: HR, quartile 4 vs. quartile 1, 1.63, 95 % CI 1.03; 2.57). We found no association for other polyphenol classes. Intake of lignans before breast cancer diagnosis may be related to improved survival among postmenopausal women, but may on the contrary worsen the survival for premenopausal women. This suggests that the role of phytoestrogens in breast cancer survival is complex and may be dependent of menopausal status.
Publication Date: 1-Nov-2015
Date of Acceptance: 5-Oct-2015
URI: http://hdl.handle.net/10044/1/60622
DOI: https://dx.doi.org/10.1007/s10549-015-3595-9
ISSN: 0167-6806
Publisher: Springer Verlag
Start Page: 389
End Page: 401
Journal / Book Title: Breast Cancer Research and Treatment
Volume: 154
Issue: 2
Copyright Statement: © 2015 Springer-Verlag. The final publication is available at Springer via https://dx.doi.org/10.1007/s10549-015-3595-9
Sponsor/Funder: University Medical Center Utrecht
Funder's Grant Number: N/A
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
Breast cancer
Survivorship
Polyphenols
Phytoestrogens
Lignans
ADJUVANT ENDOCRINE THERAPY
RECEPTOR STATUS
HEALTH
BIOAVAILABILITY
ENTEROLACTONE
METASTASIS
FLAVONOIDS
COMPONENTS
FLAXSEED
LIGNANS
Breast cancer
Lignans
Phytoestrogens
Polyphenols
Survivorship
Adult
Aged
Biomarkers, Tumor
Breast Neoplasms
Diet
Dietary Supplements
Europe
Female
Follow-Up Studies
Health Surveys
Humans
Life Style
Middle Aged
Mortality
Neoplasm Grading
Neoplasm Staging
Nutrition Surveys
Polyphenols
Proportional Hazards Models
Risk Factors
Humans
Breast Neoplasms
Neoplasm Staging
Diet
Health Surveys
Nutrition Surveys
Mortality
Proportional Hazards Models
Risk Factors
Follow-Up Studies
Life Style
Dietary Supplements
Adult
Aged
Middle Aged
Europe
Female
Polyphenols
Neoplasm Grading
Biomarkers, Tumor
Science & Technology
Life Sciences & Biomedicine
Oncology
Breast cancer
Survivorship
Polyphenols
Phytoestrogens
Lignans
ADJUVANT ENDOCRINE THERAPY
RECEPTOR STATUS
HEALTH
BIOAVAILABILITY
ENTEROLACTONE
METASTASIS
FLAVONOIDS
COMPONENTS
FLAXSEED
LIGNANS
1112 Oncology And Carcinogenesis
Oncology & Carcinogenesis
Publication Status: Published
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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