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Pharmacological aspects of closed loop insulin delivery for type 1 diabetes

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Title: Pharmacological aspects of closed loop insulin delivery for type 1 diabetes
Authors: Uduku, C
Oliver, N
Item Type: Journal Article
Abstract: Insulin deficiency and impaired glucose homeostasis are hallmarks of type 1 diabetes. Since the discovery of insulin, pharmacological and clinical developments have endeavoured to replicate its endogenous pharmacokinetics (PK) and pharmacodynamics (PD). Closed loop insulin delivery systems operate as an artificial pancreas by making automated insulin dose adjustments based on real time continuous glucose monitoring. The increasing adoption of continuous insulin pump therapy and evolving technological advances have seen significant progress in the development of closed loop insulin delivery systems. This article reviews the current landscape of closed loop insulin delivery systems and pharmacological advances that could overcome current barriers.
Issue Date: 1-Oct-2017
Date of Acceptance: 20-Jul-2017
URI: http://hdl.handle.net/10044/1/60321
DOI: https://dx.doi.org/10.1016/j.coph.2017.07.006
ISSN: 1471-4892
Start Page: 29
End Page: 33
Journal / Book Title: Current Opinion in Pharmacology
Volume: 36
Copyright Statement: © 2017 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: 1115 Pharmacology And Pharmaceutical Sciences
Pharmacology & Pharmacy
Publication Status: Published
Online Publication Date: 2017-08-10
Appears in Collections:Department of Medicine
Faculty of Medicine



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