Flow features and micro-particle deposition in a human respiratory system during sniffing

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Title: Flow features and micro-particle deposition in a human respiratory system during sniffing
Authors: Calmet, H
Houzeaux, G
Vazquez, M
Eguzkitza, B
Gambaruto, A
Bates, A
Doorly, DJ
Item Type: Journal Article
Abstract: As we inhale, the air drawn through our nose undergoes successive accelerations and decelerations as it is turned, split and recombined before splitting again at the end of the trachea as it enters the bronchi. Fully describing the dynamic behaviour of the airflow and how it transports inhaled particles poses a severe challenge to computational simulations. In this paper we explore two aspects: the dynamic behaviour of airflow during a rapid inhalation (or sniff) and the transport of inhaled aerosols. The development of flow unsteadiness from a laminar state at entry to the nose through to the turbulent character of tracheal flow is resolved using accurate numerical models with high performance computing-based large scale simulations. Combining the flow solution with a Lagrangian computation reveals the effects of flow behaviour and airway geometry on the deposition of inhaled microparticles. Improved modelling of airflow and delivery of therapeutic aerosols could be applied to improve diagnosis and treatment.
Issue Date: 1-Sep-2018
Date of Acceptance: 18-May-2018
URI: http://hdl.handle.net/10044/1/60239
DOI: https://dx.doi.org/10.1016/j.jaerosci.2018.05.008
ISSN: 0021-8502
Start Page: 171
End Page: 184
Journal / Book Title: Journal of Aerosol Science
Volume: 123
Copyright Statement: © 2018 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Biotechnology and Biological Sciences Research Council (BBSRC)
Funder's Grant Number: BB/E023444/1
Keywords: Science & Technology
Technology
Life Sciences & Biomedicine
Physical Sciences
Engineering, Chemical
Engineering, Mechanical
Environmental Sciences
Meteorology & Atmospheric Sciences
Engineering
Environmental Sciences & Ecology
Respiratory tract
Particle transport/deposition
Computational fluid-particle dynamics
HUMAN UPPER AIRWAY
NASAL PASSAGE CHARACTERISTICS
PARTICLE DEPOSITION
PATHOLOGICAL TRACHEAS
NUMERICAL-ANALYSIS
INSPIRATORY FLOW
TURBULENT FLOWS
SCALE-MODEL
TRANSPORT
SIMULATIONS
Meteorology & Atmospheric Sciences
0904 Chemical Engineering
0401 Atmospheric Sciences
Publication Status: Published
Embargo Date: 2020-05-26
Online Publication Date: 2018-05-26
Appears in Collections:Faculty of Engineering
Aeronautics



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