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A neuronal hub binding sleep initiation and body cooling in response to a warm external stimulus

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Title: A neuronal hub binding sleep initiation and body cooling in response to a warm external stimulus
Authors: Harding, E
Yu, X
Miao, A
Andrews, N
Ma, Y
Ye, Z
Lignos, L
Miracca, G
Ba, W
Yustos, R
Vyssotski, A
Wisden, W
Franks, N
Item Type: Journal Article
Abstract: Mammals, including humans, prepare for sleep by nesting and curling up, creating microclimates of skin warmth. To address if external warmth induces sleep through defined circuitry, we used c-Fos-dependent activity-tagging, which captures populations of activated cells, and allows them to be reactivated to test their physiological role. External warming tagged two principal groups of neurons in the MnPO/MPO hypothalamic area. GABA neurons located mainly in MPO produced NREM sleep but no body temperature decrease. Nitrergic/glutamatergic neurons in MnPO /MPO induced both body cooling and NREM sleep. This circuitry explains how skin warming induces sleep, and why the maximal rate of core body cooling positively correlates with sleep onset. Thus, the pathways that promote NREM-sleep, reduced energy expenditure, and body cooling are inextricably linked, commanded by the same neurons. This implies that one function of NREM sleep is to lower brain temperature and/or conserve energy.
Issue Date: 23-Jul-2018
Date of Acceptance: 18-May-2018
URI: http://hdl.handle.net/10044/1/60234
DOI: https://dx.doi.org/10.1016/j.cub.2018.05.054
ISSN: 1879-0445
Publisher: Elsevier
Start Page: 2263
End Page: 2273.e4
Journal / Book Title: Current Biology
Volume: 28
Issue: 14
Copyright Statement: © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Sponsor/Funder: Wellcome Trust
Wellcome Trust
Netherlands Organisation for Scientific Research
UK DRI Ltd
Funder's Grant Number: 107839/Z/15/Z
107841/Z/15/Z
019.161LW.010
4050641385
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
THERMOSENSORY PATHWAY
NEURAL CIRCUITRY
LEPTIN ACTION
ION-CHANNEL
TEMPERATURE
MECHANISMS
RECEPTORS
PROMOTE
TORPOR
NOS1
TetTagging
anesthesia
energy balance
hypothermia
sedation
sleep
thermoregulation
torpor
warm stimulus
Developmental Biology
06 Biological Sciences
11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
Publication Status: Published
Online Publication Date: 2018-07-12
Appears in Collections:Faculty of Natural Sciences



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