Altmetric

Exosomes in Severe Asthma: Update in Their Roles and Potential in Therapy

File Description SizeFormat 
Exosomes in Severe Asthma - Update in Their Roles and Potential in Therapy.pdfPublished version1.9 MBAdobe PDFView/Open
Title: Exosomes in Severe Asthma: Update in Their Roles and Potential in Therapy
Authors: Mortaz, E
Alipoor, SD
Varahram, M
Jamaati, H
Garssen, J
Mumby, SE
Adcock, IM
Item Type: Journal Article
Abstract: Exosomes are nanosized vesicles and have recently been recognized as important players in cell-to-cell communication. Exosomes contain different mediators such as proteins, nucleic acids (DNA, mRNA, miRNAs, and other ncRNAs), and lipid mediators and can shuttle their exosomal content to both neighboring and distal cells. Exosomes are very effective in orchestrating immune responses in the airways and all cell types can contribute to the systemic exosome pool. Intracellular communication between the broad range of cell types within the lung is crucial in disease emphasizing the importance of exosomes. In asthma, exosomes affect the inflammatory microenvironment which ultimately determines the development or alleviation of the pathological symptoms. Recent studies in this area have provided insight into the underlying mechanisms of disease and led to interest in using exosomes as potential novel therapeutic agents.
Issue Date: 8-May-2018
Date of Acceptance: 25-Mar-2018
URI: http://hdl.handle.net/10044/1/60133
DOI: https://dx.doi.org/10.1155/2018/2862187
ISSN: 2314-6133
Publisher: HINDAWI LTD
Journal / Book Title: BIOMED RESEARCH INTERNATIONAL
Volume: 2018
Copyright Statement: © 2018 Esmaeil Mortaz et al. This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Wellcome Trust
Commission of the European Communities
Funder's Grant Number: 093080/Z/10/Z
115010
Keywords: Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Medicine, Research & Experimental
Research & Experimental Medicine
CELL-DERIVED EXOSOMES
OBSTRUCTIVE PULMONARY-DISEASE
AIRWAY SMOOTH-MUSCLE
T-CELLS
DENDRITIC CELLS
MAST-CELLS
EXTRACELLULAR VESICLES
IN-VIVO
LUNG-DISEASES
B-CELLS
Publication Status: Published
Article Number: ARTN 2862187
Online Publication Date: 2018-05-08
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commons