Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

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Title: Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study
Authors: Merritt, MA
Tzoulaki, J
Van den Brandt, PA
Schouten, LJ
Tsilidis, KK
Weiderpass, E
Patel, CJ
Tjonneland, A
Hansen, L
Overvad, K
His, M
Dartois, L
Boutron-Ruault, M-C
Fortner, RT
Kaaks, R
Aleksandrova, K
Boeing, H
Trichopoulou, A
Lagiou, P
Bamia, C
Palli, D
Krogh, V
Tumino, R
Ricceri, F
Mattiello, A
Bueno-de-Mesquita, HB
Onland-Moret, NC
Peeters, PH
Skeie, G
Jareid, M
Quiros, JR
Obon-Santacana, M
Sanchez, M-J
Chamosa, S
Huerta, JM
Barricarte, A
Dias, JA
Sonestedt, E
Idahl, A
Lundin, E
Wareham, NJ
Khaw, K-T
Travis, RC
Ferrari, P
Riboli, E
Gunter, MJ
Item Type: Journal Article
Abstract: Background: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk. Objective: We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort. Design: We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs. Results: None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41). Conclusion: In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.
Issue Date: 25-Nov-2015
Date of Acceptance: 5-Oct-2015
URI: http://hdl.handle.net/10044/1/60115
DOI: https://dx.doi.org/10.3945/ajcn.115.118588
ISSN: 1938-3207
Publisher: American Society for Nutrition
Start Page: 161
End Page: 167
Journal / Book Title: American Journal of Clinical Nutrition
Volume: 103
Issue: 1
Copyright Statement: © 2016 Oxford University Press. This is a pre-copy-editing, author-produced version of an article accepted for publication in The American Journal of Clinical Nutrition following peer review. The definitive publisher-authenticated version is available online at: https://doi.org/10.3945/ajcn.115.118588
Sponsor/Funder: University Medical Center Utrecht
Funder's Grant Number: N/A
Keywords: Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
nutrition
ovarian cancer
saturated fat
serous
prospective cohort
diet
DIETARY-FAT INTAKE
SCALE PROSPECTIVE COHORT
POOLED ANALYSIS
BREAST-CANCER
RISK
QUESTIONNAIRE
HEALTH
diet
nutrition
ovarian cancer
prospective cohort
saturated fat
serous
Adult
Aged
Cohort Studies
Diet
Dietary Fats
Fatty Acids
Feeding Behavior
Female
Humans
Male
Middle Aged
Neoplasms, Glandular and Epithelial
Netherlands
Ovarian Neoplasms
Risk Factors
Humans
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
Dietary Fats
Fatty Acids
Diet
Risk Factors
Cohort Studies
Feeding Behavior
Adult
Aged
Middle Aged
Netherlands
Female
Male
11 Medical And Health Sciences
09 Engineering
Nutrition & Dietetics
Publication Status: Published
Online Publication Date: 2015-11-25
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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