Ammonium [11C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling

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Title: Ammonium [11C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling
Author(s): Haywood, T
Cesarec, S
Kealey, S
Plisson, C
Miller, P
Item Type: Journal Article
Abstract: Herein we report the preparation of ammonium [ 11 C]thiocyanate via the reaction of [ 11 C]CS 2 with ammonia. The [ 11 C]SCN − ion is demonstrated as a potent nucleophile that can be used to readily generate a range of 11 C-labelled thiocyanate molecules in high conversions. Furthermore, novel 11 C-labelled thiazolone mole- cules can be easily prepared from the intermediate α -thiocyanatophenones via an acid mediated cyclisation reaction.
Publication Date: 31-Dec-2018
Date of Acceptance: 10-May-2018
URI: http://hdl.handle.net/10044/1/60025
DOI: 10.1039/c7md00425g
ISSN: 2040-2503
Publisher: Royal Society of Chemistry
Journal / Book Title: MedChemComm
Copyright Statement: This paper is embargoed until publication. Once published it will be available fully open access.
Sponsor/Funder: The Royal Society
Engineering & Physical Science Research Council (E
Funder's Grant Number: RG110449
EP/L025140/1
Keywords: 0304 Medicinal And Biomolecular Chemistry
0305 Organic Chemistry
1115 Pharmacology And Pharmaceutical Sciences
Publication Status: Accepted
Embargo Date: publication subject to indefinite embargo
Appears in Collections:Chemistry
Catalysis and Advanced Materials
Faculty of Natural Sciences



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