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The Potential Biomarkers and Immunological Effects of Tumor-Derived Exosomes in Lung Cancer

Title: The Potential Biomarkers and Immunological Effects of Tumor-Derived Exosomes in Lung Cancer
Authors: Alipoor, SD
Mortaz, E
Varahram, M
Movassaghi, M
Kraneveld, AD
Garssen, J
Adcock, IM
Item Type: Journal Article
Abstract: Lung cancer remains the leading cause of cancer-related deaths worldwide. Despite considerable achievements in lung cancer diagnosis and treatment, the global control of the disease remains problematic. In this respect, greater understanding of the disease pathology is crucially needed for earlier diagnosis and more successful treatment to be achieved. Exosomes are nano-sized particles secreted from most cells, which allow cross talk between cells and their surrounding environment via transferring their cargo. Tumor cells, just like normal cells, also secrete exosomes that are termed Tumor-Derived Exosome or tumor-derived exosome (TEX). TEXs have gained attention for their immuno-modulatory activities, which strongly affect the tumor microenvironment and antitumor immune responses. The immunological activity of TEX influences both the innate and adaptive immune systems including natural killer cell activity and regulatory T-cell maturation as well as numerous anti-inflammatory responses. In the context of lung cancer, TEXs have been studied in order to better understand the mechanisms underlying tumor metastasis and progression. As such, TEX has the potential to act both as a biomarker for lung cancer diagnosis as well as the response to therapy.
Issue Date: 18-Apr-2018
Date of Acceptance: 4-Apr-2018
URI: http://hdl.handle.net/10044/1/59968
DOI: https://dx.doi.org/10.3389/fimmu.2018.00819
ISSN: 1664-3224
Publisher: FRONTIERS MEDIA SA
Journal / Book Title: FRONTIERS IN IMMUNOLOGY
Volume: 9
Copyright Statement: © 2018 Alipoor, Mortaz, Varahram, Movassaghi, Kraneveld, Garssen and Adcock. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
tumor-derived exosome
lung tumor
exosomes
microRNA
NSCLC
EPITHELIAL-MESENCHYMAL TRANSITION
PRE-METASTATIC NICHE
REGULATORY B-CELLS
SUPPRESSOR-CELLS
T-CELLS
EXTRACELLULAR VESICLES
BREAST-CANCER
RELEASED MICROVESICLES
ADENOCARCINOMA CELLS
PREMETASTATIC NICHE
Publication Status: Published
Article Number: ARTN 819
Online Publication Date: 2018-04-18
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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