Altmetric

Effects of psilocybin therapy on personality structure

File Description SizeFormat 
Erritzoe_et_al-2018-Acta_Psychiatrica_Scandinavica.pdfPublished version237.2 kBAdobe PDFView/Open
Title: Effects of psilocybin therapy on personality structure
Authors: Erritzoe, D
Roseman, L
Nour, MM
MacLean, K
Kaelen, M
Nutt, DJ
Carhart-Harris, RL
Item Type: Journal Article
Abstract: Objective To explore whether psilocybin with psychological support modulates personality parameters in patients suffering from treatment‐resistant depression (TRD). Method Twenty patients with moderate or severe, unipolar, TRD received oral psilocybin (10 and 25 mg, one week apart) in a supportive setting. Personality was assessed at baseline and at 3‐month follow‐up using the Revised NEO Personality Inventory (NEO‐PI‐R), the subjective psilocybin experience with Altered State of Consciousness (ASC) scale, and depressive symptoms with QIDS‐SR16. Results Neuroticism scores significantly decreased while Extraversion increased following psilocybin therapy. These changes were in the direction of the normative NEO‐PI‐R data and were both predicted, in an exploratory analysis, by the degree of insightfulness experienced during the psilocybin session. Openness scores also significantly increased following psilocybin, whereas Conscientiousness showed trend‐level increases, and Agreeableness did not change. Conclusion Our observation of changes in personality measures after psilocybin therapy was mostly consistent with reports of personality change in relation to conventional antidepressant treatment, although the pronounced increases in Extraversion and Openness might constitute an effect more specific to psychedelic therapy. This needs further exploration in future controlled studies, as do the brain mechanisms of postpsychedelic personality change.
Issue Date: 1-Nov-2018
Date of Acceptance: 6-May-2018
URI: http://hdl.handle.net/10044/1/59867
DOI: https://dx.doi.org/10.1111/acps.12904
ISSN: 1600-0447
Publisher: Wiley
Start Page: 368
End Page: 378
Journal / Book Title: Acta Psychiatrica Scandinavica
Volume: 138
Issue: 5
Copyright Statement: © 2018 The Authors. Acta Psychiatrica Scandinavica Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Science & Technology
Life Sciences & Biomedicine
Psychiatry
depression
personality
NEO-PI-R
Openness
psilocybin
psychedelic
TREATMENT-RESISTANT DEPRESSION
LIFE-THREATENING CANCER
ACID DIETHYLAMIDE LSD
ASSISTED PSYCHOTHERAPY
POLITICAL ORIENTATION
MAJOR DEPRESSION
RECEPTOR-BINDING
BIG 5
DISORDER
PSYCHEDELICS
NEO-PI-R
Openness
depression
personality
psilocybin
psychedelic
11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
Psychiatry
Publication Status: Published
Online Publication Date: 2018-06-19
Appears in Collections:Department of Medicine
Faculty of Medicine



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commons