Altmetric

Human T-cell leukaemia virus type 1: parasitism and pathogenesis

File Description SizeFormat 
Human T-cell leukaemia virus type 1: parasitism and pathogenesis.pdfPublished version664.76 kBAdobe PDFView/Open
Title: Human T-cell leukaemia virus type 1: parasitism and pathogenesis
Authors: Bangham, CRM
Matsuoka, M
Item Type: Journal Article
Abstract: Human T-cell leukaemia virus type 1 (HTLV-1) causes not only adult T-cell leukaemia-lymphoma (ATL), but also inflammatory diseases including HTLV-1-associated myelopathy/tropical spastic paraparesis. HTLV-1 transmits primarily through cell-to-cell contact, and generates abundant infected cells in the host in order to survive and transmit to a new host. The resulting high proviral load is closely associated with the development of ATL and inflammatory diseases. To increase the number of infected cells, HTLV-1 changes the immunophenotype of infected cells, induces proliferation and inhibits apoptosis through the cooperative actions of two viral genes, tax and HTLV-1 bZIP factor (HBZ). As a result, infected cells survive, proliferate and infiltrate into the tissues, which is critical for transmission of the virus. Thus, the strategy of this virus is indivisibly linked with its pathogenesis, providing a clue for prevention and treatment of HTLV-1-induced diseases.
Issue Date: 19-Oct-2017
Date of Acceptance: 9-Jun-2017
URI: http://hdl.handle.net/10044/1/59850
DOI: https://dx.doi.org/10.1098/rstb.2016.0272
ISSN: 0962-8436
Publisher: Royal Society
Journal / Book Title: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume: 372
Issue: 1732
Copyright Statement: © 2017 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Keywords: Science & Technology
Life Sciences & Biomedicine
Biology
Life Sciences & Biomedicine - Other Topics
HTLV-1
Tax
HBZ
I-ASSOCIATED MYELOPATHY
TROPICAL SPASTIC PARAPARESIS
LONG TERMINAL REPEAT
NF-KAPPA-B
HTLV-I
INFECTED-CELLS
CLONAL EXPANSION
MEDIATED APOPTOSIS
ANTI-CCR4 ANTIBODY
NATURAL INFECTION
HBZ
HTLV-1
Tax
HTLV-I Infections
Human T-lymphotropic virus 1
Humans
Leukemia-Lymphoma, Adult T-Cell
Humans
Human T-lymphotropic virus 1
HTLV-I Infections
Leukemia-Lymphoma, Adult T-Cell
Science & Technology
Life Sciences & Biomedicine
Biology
Life Sciences & Biomedicine - Other Topics
HTLV-1
Tax
HBZ
I-ASSOCIATED MYELOPATHY
TROPICAL SPASTIC PARAPARESIS
LONG TERMINAL REPEAT
NF-KAPPA-B
HTLV-I
INFECTED-CELLS
CLONAL EXPANSION
MEDIATED APOPTOSIS
ANTI-CCR4 ANTIBODY
NATURAL INFECTION
06 Biological Sciences
11 Medical And Health Sciences
Evolutionary Biology
Publication Status: Published
Article Number: ARTN 20160272
Online Publication Date: 2017-10-19
Appears in Collections:Department of Medicine
Faculty of Medicine



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commonsx