Nonsteroidal anti-inflammatory drug use and breast cancer risk in a European prospective cohort study

Title: Nonsteroidal anti-inflammatory drug use and breast cancer risk in a European prospective cohort study
Authors: Cairat, M
Fournier, A
Murphy, N
Biessy, C
Scalbert, A
Rinaldi, S
Tjønneland, A
Olsen, A
Overvad, K
Arveux, P
Boutron-Ruault, M-C
Cadeau, C
Fortner, RT
Kaaks, R
Boeing, H
Aleksandrova, K
Peeters, PHM
Van Gils, CH
Wareham, NJ
Khaw, K-T
Aune, D
Riboli, E
Gunter, MJ
Dossus, L
Item Type: Journal Article
Abstract: Experimental studies have shown a protective effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer development. However, results from epidemiological cohort studies are less consistent. Our objective was to assess the association between NSAID use and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 European countries. Self-reported information on NSAID use at baseline has been collected in five EPIC countries. Multivariable Cox regression models were used to estimate hazard ratios for the association of NSAID use with breast cancer incidence with adjustment for potential confounders. We also assessed effect modification by breast cancer risk factors and examined the associations within specific breast cancer subtypes. Among the 140,981 women included in the analysis, 7% were regularly using NSAIDs at baseline. During a median follow-up time period of 13 years, 7,379 incident breast cancer cases were diagnosed (816 in situ and 6,563 invasive). There were no statistically significant associations between NSAID use and breast cancer risk, overall and by subtypes. However, a statistically significant interaction was observed for invasive cases between NSAID use and ever use of menopausal hormonal therapy (MHT) among postmenopausal women [MHT users: HRNSAID use =0.84 (0.73 - 0.96); non MHT users: HRNSAID use = 1.08 (0.93 - 1.25); Pinteraction = 0.05]. Our results indicate potential effect modification of MHT use on the association between use of NSAIDs and breast cancer risk which deserves in-depth investigation in studies with accurate data on both NSAID and MHT use.
Issue Date: 1-Oct-2018
Date of Acceptance: 7-Mar-2018
ISSN: 0020-7136
Publisher: Wiley
Start Page: 1688
End Page: 1695
Journal / Book Title: International Journal of Cancer
Volume: 143
Issue: 7
Copyright Statement: © 2018 UICC. This is the accepted version of the following article, which has been published in final form at
Keywords: Science & Technology
Life Sciences & Biomedicine
breast cancer
nonsteroidal anti-inflammatory agents
cohort studies
postmenopausal hormone replacement therapy
breast cancer
cohort studies
nonsteroidal anti-inflammatory agents
postmenopausal hormone replacement therapy
Oncology & Carcinogenesis
1112 Oncology and Carcinogenesis
Publication Status: Published
Conference Place: United States
Online Publication Date: 2018-07-24
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care

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