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ON-OFF receptive fields in auditory cortex diverge during development and contribute to directional sweep selectivity

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Title: ON-OFF receptive fields in auditory cortex diverge during development and contribute to directional sweep selectivity
Authors: Sollini, J
Chapuis, GA
Clopath, C
Chadderton, PT
Item Type: Journal Article
Abstract: Neurons in the auditory cortex exhibit distinct frequency tuning to the onset and offset of sounds, but the cause and significance of ON and OFF receptive field (RF) organisation are not understood. Here we demonstrate that distinct ON and OFF frequency tuning is largely absent in immature mouse auditory cortex and is thus a consequence of cortical development. Simulations using a novel implementation of a standard Hebbian plasticity model show that the natural alternation of sound onset and offset is sufficient for the formation of non-overlapping adjacent ON and OFF RFs in cortical neurons. Our model predicts that ON/OFF RF arrangement contributes towards direction selectivity to frequency-modulated tone sweeps, which we confirm by neuronal recordings. These data reveal that a simple and universally accepted learning rule can explain the organisation of ON and OFF RFs and direction selectivity in the developing auditory cortex.
Issue Date: 25-May-2018
Date of Acceptance: 3-May-2018
URI: http://hdl.handle.net/10044/1/59784
DOI: https://dx.doi.org/10.1038/s41467-018-04548-3
ISSN: 2041-1723
Publisher: Nature Publishing Group
Journal / Book Title: Nature Communications
Volume: 9
Copyright Statement: © The Author(s) 2018. This article is licensed under a Creative CommonsAttribution 4.0 International License, which permits use, sharing,adaptation, distribution and reproduction in any medium or format, as long as you giveappropriate credit to the original author(s) and the source, provide a link to the CreativeCommons license, and indicate if changes were made. The images or other third partymaterial in this article are included in the article’s Creative Commons license, unlessindicated otherwise in a credit line to the material. If material is not included in thearticle’s Creative Commons license and your intended use is not permitted by statutoryregulation or exceeds the permitted use, you will need to obtain permission directly fromthe copyright holder. To view a copy of this license, visithttp://creativecommons.org/licenses/by/4.0/
Sponsor/Funder: Medical Research Council (MRC)
Human Frontier Science Program
Medical Research Foundation
Biotechnology and Biological Sciences Research Council (BBSRC)
Wellcome Trust
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Cou
Funder's Grant Number: G1000512
RGY089/2012
C0488
BB/N008871/1
200790/Z/16/Z
BB/P018785/1
ORCA 64155 (BB/N013956/1)
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
FREQUENCY-MODULATED SWEEPS
RESPONSES
CONNECTIVITY
TOPOGRAPHY
NEURONS
INTERNEURONS
COMPETITION
ACTIVATION
PLASTICITY
CELLS
Acoustic Stimulation
Action Potentials
Animals
Auditory Cortex
Auditory Perception
Brain Mapping
Evoked Potentials, Auditory
Female
Learning
Male
Mice, Inbred C57BL
Mice, Transgenic
Neurons
Reaction Time
Auditory Cortex
Neurons
Animals
Mice, Inbred C57BL
Mice, Transgenic
Acoustic Stimulation
Brain Mapping
Learning
Auditory Perception
Reaction Time
Evoked Potentials, Auditory
Action Potentials
Female
Male
MD Multidisciplinary
Publication Status: Published
Article Number: ARTN 2084
Appears in Collections:Faculty of Engineering
Bioengineering



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