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Treatment of obesity in young people – A systematic review and meta analysis

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Title: Treatment of obesity in young people – A systematic review and meta analysis
Authors: Selvendran, S
Penney, NC
Aggarwal, N
Darzi, A
Purkayastha, S
Item Type: Journal Article
Abstract: Purpose: Obesity in the young is increasingly prevalent. Early, effective intervention is paramount. Treatment options are: lifestyle modifications, pharmacological therapies, endoscopic treatments and bariatric surgery. However, the relative effectiveness of these treatments in young patients remains unclear. Material and Methods: We systematically identify and meta-analyse studies evaluating weight-loss treatments in young people (<21yrs) with obesity. Results: From 16372 identified studies, 83 were eligible for meta-analysis. Bariatric surgery resulted in high short/medium term weight loss [pooled-estimate: 14.04kg/m2]. Lifestyle and pharmacological therapies impacted weight more moderately [pooled-estimate: 0.99kg/m2 and 0.94kg/m2 respectively]. Conclusion: Due to its high efficacy, bariatric surgery should be considered earlier when treating obesity in young people. However, due to the invasiveness and inherent risks of bariatric surgery, all other weight loss routes should be exhausted first.
Issue Date: 1-Aug-2018
Date of Acceptance: 25-Apr-2018
URI: http://hdl.handle.net/10044/1/59289
DOI: https://dx.doi.org/10.1007/s11695-018-3285-x
ISSN: 0960-8923
Publisher: Springer Verlag
Start Page: 2537
End Page: 2549
Journal / Book Title: Obesity Surgery
Volume: 28
Issue: 8
Copyright Statement: © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Science & Technology
Life Sciences & Biomedicine
Surgery
Obesity
Young people
Bariatric surgery
Diet
Lifestyle
Metabolic surgery
LAPAROSCOPIC SLEEVE GASTRECTOMY
RANDOMIZED CONTROLLED-TRIAL
Y GASTRIC BYPASS
BARIATRIC SURGERY
WEIGHT-LOSS
PEDIATRIC-PATIENTS
FOLLOW-UP
OVERWEIGHT CHILDREN
ADOLESCENT OBESITY
CHILDHOOD OBESITY
1103 Clinical Sciences
1117 Public Health And Health Services
Publication Status: Published
Online Publication Date: 2018-05-23
Appears in Collections:Division of Surgery
Faculty of Medicine



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