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Exhaled nitric oxide is not a biomarker for pulmonary tuberculosis

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Title: Exhaled nitric oxide is not a biomarker for pulmonary tuberculosis
Authors: Lopez, J
Loader, M
Smith, D
Pastorius, D
Bravard, M
Caviedes, L
Romero, K
Clark, T
Checkley, W
Ticona, E
Friedland, JS
Gilman, R
Item Type: Journal Article
Abstract: To reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an easily measured, non-invasive potential biomarker for diagnosis and monitoring of treatment response in participants with pulmonary TB including multi-drug resistant (MDR)-TB in Lima, Peru. In a longitudinal study however, we found no differences in baseline median FeNO levels between 38 TB participants and 93 age-matched controls (13 parts per billion (ppb) (IQR 8-26), vs. 15 ppb (IQR 12-24)), and there was no change over 60 days of treatment (15 ppb (IQR 10-19) at day 60). Taking this and previous evidence together we conclude FeNO is not of value in either the diagnosis of pulmonary TB nor as a marker of treatment response.
Issue Date: 1-Jun-2018
Date of Acceptance: 27-Feb-2018
URI: http://hdl.handle.net/10044/1/59246
DOI: https://dx.doi.org/10.4269/ajtmh.17-0425
ISSN: 0002-9637
Publisher: American Society of Tropical Medicine and Hygiene
Start Page: 1637
End Page: 1639
Journal / Book Title: American Journal of Tropical Medicine and Hygiene
Volume: 98
Issue: 6
Copyright Statement: © The American Society of Tropical Medicine and Hygiene [open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited (https://creativecommons.org/licenses/by/4.0/)
Keywords: 11 Medical And Health Sciences
Tropical Medicine
Publication Status: Published
Online Publication Date: 2018-04-30
Appears in Collections:Department of Medicine
Faculty of Medicine



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