Exhaled nitric oxide is not a biomarker for pulmonary tuberculosis

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Title: Exhaled nitric oxide is not a biomarker for pulmonary tuberculosis
Authors: Lopez, J
Loader, M
Smith, D
Pastorius, D
Bravard, M
Caviedes, L
Romero, K
Clark, T
Checkley, W
Ticona, E
Friedland, JS
Gilman, R
Item Type: Journal Article
Abstract: To reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an easily measured, non-invasive potential biomarker for diagnosis and monitoring of treatment response in participants with pulmonary TB including multi-drug resistant (MDR)-TB in Lima, Peru. In a longitudinal study however, we found no differences in baseline median FeNO levels between 38 TB participants and 93 age-matched controls (13 parts per billion (ppb) (IQR 8-26), vs. 15 ppb (IQR 12-24)), and there was no change over 60 days of treatment (15 ppb (IQR 10-19) at day 60). Taking this and previous evidence together we conclude FeNO is not of value in either the diagnosis of pulmonary TB nor as a marker of treatment response.
Issue Date: 1-Jun-2018
Date of Acceptance: 27-Feb-2018
ISSN: 0002-9637
Publisher: American Society of Tropical Medicine and Hygiene
Start Page: 1637
End Page: 1639
Journal / Book Title: American Journal of Tropical Medicine and Hygiene
Volume: 98
Issue: 6
Copyright Statement: © The American Society of Tropical Medicine and Hygiene [open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited (
Keywords: 11 Medical And Health Sciences
Tropical Medicine
Publication Status: Published
Online Publication Date: 2018-04-30
Appears in Collections:Department of Medicine
Faculty of Medicine

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