Common signalling pathways in macrophage and osteoclast multinucleation

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Title: Common signalling pathways in macrophage and osteoclast multinucleation
Author(s): Pereira, M
Petretto, E
Gordon, S
Bassett, JHD
Williams, GR
Behmoaras, JV
Item Type: Journal Article
Abstract: Macrophage cell fusion and multinucleation are fundamental processes in the formation of multinucleated giant cells (MGCs) in chronic inflammatory disease and osteoclasts in the regulation of bone mass. However, this basic cell phenomenon is poorly understood despite its pathophysiological relevance. Granulomas containing multinucleated giant cells are seen in a wide variety of complex inflammatory disorders, as well as in infectious diseases. Dysregulation of osteoclastic bone resorption underlies the pathogenesis of osteoporosis and malignant osteolytic bone disease. Recent reports have shown that the formation of multinucleated giant cells and osteoclast fusion display a common molecular signature, suggesting shared genetic determinants. In this Review, we describe the background of cell–cell fusion and the similar origin of macrophages and osteoclasts. We specifically focus on the common pathways involved in osteoclast and MGC fusion. We also highlight potential approaches that could help to unravel the core mechanisms underlying bone and granulomatous disorders in humans.
Publication Date: 5-Jun-2018
Date of Acceptance: 16-Apr-2018
URI: http://hdl.handle.net/10044/1/59143
DOI: https://dx.doi.org/10.1242/jcs.216267
ISSN: 0021-9533
Publisher: Company of Biologists
Journal / Book Title: Journal of Cell Science
Volume: 131
Issue: 11
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Funder's Grant Number: MR/M004716/1
MR/N01121X/1
Copyright Statement: © 2018. Published by The Company of Biologists Ltd
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
fusion
Macrophages
Multinucleation
Osteoclasts
GIANT-CELL FORMATION
COLONY-STIMULATING FACTOR
TUMOR-NECROSIS-FACTOR
MOUSE BONE-MARROW
GRANULOMA-FORMATION
DENDRITIC CELLS
FACTOR-I
MYCOBACTERIUM-TUBERCULOSIS
ALPHA-V-BETA-3 INTEGRIN
MONONUCLEAR PHAGOCYTES
Cell fusion
Macrophages
Multinucleation
Osteoclasts
06 Biological Sciences
11 Medical And Health Sciences
Developmental Biology
Publication Status: Published
Embargo Date: 2019-06-05
Appears in Collections:Clinical Sciences
Molecular Sciences
Department of Medicine
Faculty of Medicine



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