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Understanding heterogeneities in mosquito-bite exposure and infection distributions for the elimination of lymphatic filariasis

Title: Understanding heterogeneities in mosquito-bite exposure and infection distributions for the elimination of lymphatic filariasis
Authors: Irvine, MA
Kazura, JW
Hollingsworth, TD
Reimer, LJ
Item Type: Journal Article
Abstract: It is well known that individuals in the same community can be exposed to a highly variable number of mosquito bites. This heterogeneity in bite exposure has consequences for the control of vector-borne diseases because a few people may be contributing significantly to transmission. However, very few studies measure sources of heterogeneity in a way which is relevant to decision-making. We investigate the relationship between two classic measures of heterogeneity, spatial and individual, within the context of lymphatic filariasis, a parasitic mosquito-borne disease. Using infection and mosquito-bite data for five villages in Papua New Guinea, we measure biting characteristics to model what impact bed-nets have had on control of the disease. We combine this analysis with geospatial modelling to understand the spatial relationship between disease indicators and nightly mosquito bites. We found a weak association between biting and infection heterogeneity within villages. The introduction of bed-nets increased biting heterogeneity, but the reduction in mean biting more than compensated for this, by reducing prevalence closer to elimination thresholds. Nightly biting was explained by a spatial heterogeneity model, while parasite load was better explained by an individual heterogeneity model. Spatial and individual heterogeneity are qualitatively different with profoundly different policy implications.
Issue Date: 31-Jan-2018
Date of Acceptance: 8-Jan-2018
URI: http://hdl.handle.net/10044/1/59097
DOI: https://dx.doi.org/10.1098/rspb.2017.2253
ISSN: 0962-8452
Publisher: Royal Society
Journal / Book Title: PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume: 285
Issue: 1871
Copyright Statement: © 2018 The Author(s). Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Keywords: Science & Technology
Life Sciences & Biomedicine
Biology
Ecology
Evolutionary Biology
Life Sciences & Biomedicine - Other Topics
Environmental Sciences & Ecology
lymphatic filariasis
bite heterogeneity
vector control
geospatial model
spatial heterogeneity
PAPUA-NEW-GUINEA
SPATIAL HETEROGENEITY
MALARIA TRANSMISSION
WUCHERERIA-BANCROFTI
MATHEMATICAL-MODELS
DISEASE
HOST
INTERVENTIONS
SELECTION
DYNAMICS
06 Biological Sciences
11 Medical And Health Sciences
07 Agricultural And Veterinary Sciences
Publication Status: Published
Article Number: ARTN 20172253
Online Publication Date: 2018-01-31
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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