Adherence to quality criteria improves concordance between transient elastography and ElastPQ for liver stiffness assessment-A multicenter retrospective study

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Title: Adherence to quality criteria improves concordance between transient elastography and ElastPQ for liver stiffness assessment-A multicenter retrospective study
Authors: Ferraioli, G
De Silvestri, A
Reiberger, T
Taylor-Robinson, SD
De Knegt, RJ
Maiocchi, L
Mare, R
Bucsics, T
Atzori, S
Tinelli, C
Sporea, I
Item Type: Journal Article
Abstract: BACKGROUND: Assessment of liver stiffness provides important diagnostic and prognostic information in patients with chronic liver disease. AIMS: To investigate whether the use of quality criteria (i) improves the concordance between transient elastography (TE) and a novel point shear wave elastography technique (ElastPQ®) and (ii) impacts on the performance of ElastPQ® for liver fibrosis staging using TE as the reference standard. METHODS: In this multicenter retrospective study, data of patients undergoing liver stiffness measurements (LSM) in five European centers were collected. TE was performed with FibroScan® (Echosens, France) and ElastPQ® with EPIQ® or Affiniti® systems (Philips, The Netherlands). The agreement between TE and ElastPQ® LSMs was assessed with Lin's concordance correlation coefficient (CCC). Diagnostic performance of ElastPQ® was assessed by the area under receiver operating characteristic (AUROC) curves. RESULTS: Overall, 664 patients were included: mean age: 54.8(13.5) years, main etiologies: viral hepatitis (83.1%) and NAFLD (7.5%). CCC increased significantly when LSMs with ElastPQ® were obtained with IQR/M ≤ 30% (p < 0.001). The diagnostic performance of ElastPQ® for fibrosis staging also increased if LSM values were obtained with IQR/M ≤ 30%. CONCLUSION: Quality criteria should be followed when using ElastPQ® for LSM, since the concordance with TE fibrosis staging was better at an ElastPQ® IQR/M ≤ 30.
Issue Date: Oct-2018
Date of Acceptance: 26-Mar-2018
URI: http://hdl.handle.net/10044/1/59093
DOI: https://doi.org/10.1016/j.dld.2018.03.033
ISSN: 1590-8658
Publisher: Elsevier
Start Page: 1056
End Page: 1061
Journal / Book Title: Digestive and Liver Disease
Volume: 50
Issue: 10
Copyright Statement: © 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Imperial College Healthcare Charity
Funder's Grant Number: 5101
Keywords: Science & Technology
Life Sciences & Biomedicine
Gastroenterology & Hepatology
Diagnostic performance
Liver fibrosis
Multicenter studies
Quality criteria
Shear wave elastography
CHRONIC HEPATITIS-C
SHEAR-WAVE ELASTOGRAPHY
ULTRASOUND ELASTOGRAPHY
POINT QUANTIFICATION
CLINICAL-USE
FIBROSIS
ACCURACY
RECOMMENDATIONS
GUIDELINES
DIAGNOSIS
Diagnostic performance
Liver fibrosis
Multicenter studies
Quality criteria
Shear wave elastography
Adult
Aged
Area Under Curve
Elasticity Imaging Techniques
Europe
Female
Guideline Adherence
Humans
Liver
Liver Cirrhosis
Male
Middle Aged
ROC Curve
Reproducibility of Results
Retrospective Studies
Severity of Illness Index
Liver
Humans
Liver Cirrhosis
Severity of Illness Index
Area Under Curve
Retrospective Studies
Reproducibility of Results
ROC Curve
Adult
Aged
Middle Aged
Guideline Adherence
Europe
Female
Male
Elasticity Imaging Techniques
Diagnostic performance
Liver fibrosis
Multicenter studies
Quality criteria
Shear wave elastography
1103 Clinical Sciences
Gastroenterology & Hepatology
Publication Status: Published online
Conference Place: Netherlands
Online Publication Date: 2018-04-04
Appears in Collections:Division of Surgery
Faculty of Medicine



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