Patient-centered practice in elderly myeloma patients: an overview and consensus from the European Myeloma Network (EMN)

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Title: Patient-centered practice in elderly myeloma patients: an overview and consensus from the European Myeloma Network (EMN)
Authors: Larocca, A
Dold, SM
Zweegman, S
Terpos, E
Waesch, R
D'Agostino, M
Scheubeck, S
Goldschmidt, H
Gay, F
Cavo, M
Ludwig, H
Straka, C
Bringhen, S
Auner, HW
Caers, J
Gramatzki, M
Offidani, M
Dimopoulos, MA
Einsele, H
Boccadoro, M
Sonneveld, P
Engelhardt, M
Item Type: Journal Article
Abstract: Multiple myeloma is a disease typical of the elderly, and, because of the increase in life expectancy of the general population, its incidence is expected to grow in the future. Elderly patients represent a particular challenge due to their marked hete rogeneity. Many new and highly effective drugs have been introduced in the last few years, and resu lts from clinical trials are promising. Besides the availability of novel agents, a careful evaluation of elderly patients showed to be a key factor for the success of therapy. A geriatric assessment is a valid strategy to better stratify patients. In particular, different scores are available today to appropriately assess elderly patients and define their fitness/frailty status. The choice of treatm ent – transplantation, triplets, doublets, or reduced- dose therapies including novel agents – should depend on the patient’s fitness status (fit, intermediate-fit or frail). Second-generation no vel agents have also been evaluated as salvage therapy in the elderly, and these new agents certai nly represent a further step forward in the treatment armamentarium for elderly patients with multiple myeloma.
Issue Date: 25-Apr-2018
Date of Acceptance: 9-Apr-2018
URI: http://hdl.handle.net/10044/1/58981
DOI: https://d.xdoi.org/10.1038/s41375-018-0142-9
ISSN: 1476-5551
Publisher: Nature Publishing Group
Start Page: 1697
End Page: 1712
Journal / Book Title: Leukemia
Volume: 32
Copyright Statement: © Macmillan Publishers Limited, part of Springer Nature 2018
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
Hematology
DIAGNOSED MULTIPLE-MYELOMA
STEM-CELL TRANSPLANTATION
COMPREHENSIVE GERIATRIC ASSESSMENT
BORTEZOMIB-MELPHALAN-PREDNISONE
LOW-DOSE DEXAMETHASONE
COMORBIDITY INDEX
WORKING GROUP
OPEN-LABEL
DARATUMUMAB MONOTHERAPY
RANDOMIZED-TRIALS
1103 Clinical Sciences
1112 Oncology And Carcinogenesis
Immunology
Publication Status: Published
Online Publication Date: 2018-04-25
Appears in Collections:Department of Medicine
Faculty of Medicine



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