Altmetric

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

File Description SizeFormat 
1-s2.0-S0092867417305846-main.pdfPublished version8.68 MBAdobe PDFView/Open
Title: Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields
Authors: Grossman, N
Bono, D
Dedic, N
Kodandaramaiah, SB
Rudenko, A
Suk, H-J
Cassara, AM
Neufeld, E
Kuster, N
Tsai, L-H
Pascual-Leone, A
Boyden, ES
Item Type: Journal Article
Abstract: We report a noninvasive strategy for electrically stimulating neurons at depth. By delivering to the brain multiple electric fields at frequencies too high to recruit neural firing, but which differ by a frequency within the dynamic range of neural firing, we can electrically stimulate neurons throughout a region where interference between the multiple fields results in a prominent electric field envelope modulated at the difference frequency. We validated this temporal interference (TI) concept via modeling and physics experiments, and verified that neurons in the living mouse brain could follow the electric field envelope. We demonstrate the utility of TI stimulation by stimulating neurons in the hippocampus of living mice without recruiting neurons of the overlying cortex. Finally, we show that by altering the currents delivered to a set of immobile electrodes, we can steerably evoke different motor patterns in living mice.
Issue Date: 1-Jun-2017
Date of Acceptance: 12-May-2017
URI: http://hdl.handle.net/10044/1/58974
DOI: https://dx.doi.org/10.1016/j.cell.2017.05.024
ISSN: 0092-8674
Publisher: CELL PRESS
Start Page: 1029
End Page: 1041.e16
Journal / Book Title: CELL
Volume: 169
Issue: 6
Copyright Statement: © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
FREQUENCY ALTERNATING-CURRENT
MOTOR CORTEX
NEURONS
MICROSTIMULATION
LOCALIZATION
MARKER
HDAC1
brain
cortex
deep brain stimulation
electromagnetic
hippocampus
neuromodulation
noninvasive
optogenetics
transcranial direct current stimulation
transcranial magnetic stimulation
Animals
Deep Brain Stimulation
Electrodes
Hippocampus
Male
Mice
Mice, Inbred C57BL
Neurons
Transcranial Direct Current Stimulation
06 Biological Sciences
11 Medical And Health Sciences
Developmental Biology
Publication Status: Published
Online Publication Date: 2017-06-01
Appears in Collections:Department of Medicine
Faculty of Medicine



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commons