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Recent Asian origin of chytrid fungi causing global amphibian declines

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Title: Recent Asian origin of chytrid fungi causing global amphibian declines
Author(s): O'Hanlon, SJ
Rieux, A
Farrer, R
Rosa, G
Waldman, B
Bataille, A
Kosch, T
Murray, K
Brankovics, B
Fumagalli, M
Martin, M
Wales, N
Alvarado-Rybak, M
Bates, K
Berger, L
Böll, S
Brookes, L
Clare, F
Courtois, E
Cunningham, A
Doherty-Bone, T
Ghosh, P
Gower, D
Hintz, W
Höglund, J
Jenkinson, T
Lin, C-F
Laurila, A
Loyau, A
Martel, A
Meurling, S
Miaud, C
Minting, P
Pasmans, F
Schmeller, D
Schmidt, B
Shelton, J
Tessa, G
Toledo, LF
Valenzuela-Sánchez, A
Verster, R
Vörös, J
Webb, R
Wierzbicki, C
Wombwell, E
Zamudio, K
Aanensen, D
James, T
Gilbert, MTP
Weldon, C
Bosch, J
Balloux, F
Garner, T
Fisher, M
Item Type: Journal Article
Abstract: Globalized infectious diseases are causing species declines worldwide but their source often remains elusive. We use whole-genome sequencing to solve the spatiotemporal origins of the most devastating panzootic to date, caused by the fungus Batrachochytrium dendrobatidis, a proximate driver of global amphibian declines. We trace the source of B. dendrobatidis to the Korean peninsula where one lineage, BdASIA-1, exhibits the genetic hallmarks of an ancestral population that seeded the panzootic. We date the emergence of this pathogen to the early 20th century coinciding with the global expansion of commercial trade in amphibians and show that intercontinental transmission is ongoing. Our findings point to East Asia as a geographic hotspot for B. dendrobatidis biodiversity, and the original source of these lineages that now parasitize amphibians worldwide.
Editor(s): Ash, C
Publication Date: 11-May-2018
Date of Acceptance: 29-Mar-2018
URI: http://hdl.handle.net/10044/1/58830
DOI: 10.1126/science.aar1965
ISSN: 0036-8075
Publisher: AAAS
Journal / Book Title: Science
Sponsor/Funder: Natural Environment Research Council (NERC)
Natural Environment Research Council (NERC)
The Leverhulme Trust
Morris Animal Foundation
Funder's Grant Number: NE/G001944/1
NE/K014455/1
RPG-2014-273
D16ZO-022
Keywords: genomics
MD Multidisciplinary
General Science & Technology
Publication Status: Accepted
Embargo Date: publication subject to indefinite embargo
Online Publication Date: 2018-05-11
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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