The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics

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Title: The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics
Authors: De Francesco, D
Wit, FW
Cole, JH
Kootstra, NA
Winston, A
Sabin, CA
Underwood, J
Van Zoest, RA
Schouten, J
Kooij, KW
Prins, M
Guaraldi, G
Caan, MWA
Burger, D
Franceschi, C
Libert, C
Bürkle, A
Reiss, P
COmorBidity in Relation to AIDS (COBRA) collaboration
Item Type: Journal Article
Abstract: BACKGROUND: Persons living with HIV on combination antiretroviral therapy (cART) may be at increased risk of the development of age-associated non-communicable comorbidities (AANCC) at relatively young age. It has therefore been hypothesised that such individuals, despite effective cART, may be prone to accelerated aging. OBJECTIVE: The COmorBidity in Relation to AIDS (COBRA) cohort study was designed to investigate the potential causal link between HIV and AANCC, amongst others, in a cohort of middle-aged individuals with HIV with sustained viral suppression on cART and otherwise comparable HIV-negative controls. METHODS: Longitudinal cohort study of HIV-positive subjects ≥45 years of age, with sustained HIV suppression on cART recruited from two large European HIV treatment centres and similarly-aged HIV-negative controls recruited from sexual health centres and targeted community groups. Both HIV-positive and HIV-negative subjects were assessed at study entry and again at follow-up after 2 years. RESULTS: Of the 134 HIV-positive individuals with a median (IQR) age of 56 (51, 62) years recruited, 93% were male, 88% of white ethnicity and 86% were men who have sex with men (MSM). Similarly, the 79 HIV-negative subjects had a median (IQR) age of 57 (52, 64) and 92% were male, 97% of white ethnicity and 80% were MSM. CONCLUSIONS: The results from the COBRA study will be a significant resource to understand the link between HIV and AANCC and the pathogenic mechanisms underlying this link. COBRA will inform future development of novel prognostic tools for earlier diagnosis of AANCC and of novel interventions which, as an adjunct to cART, may prevent AANCC.
Issue Date: 29-Mar-2018
Date of Acceptance: 11-Jan-2018
URI: http://hdl.handle.net/10044/1/58554
DOI: https://dx.doi.org/10.1371/journal.pone.0191791
ISSN: 1932-6203
Publisher: Public Library of Science (PLoS)
Journal / Book Title: PLoS ONE
Volume: 13
Issue: 3
Copyright Statement: © 2018 Francesco et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: MD Multidisciplinary
General Science & Technology
Publication Status: Published
Conference Place: United States
Article Number: e0191791
Appears in Collections:Department of Medicine
Faculty of Medicine



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