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Tuberculosis susceptibility and protection in children

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Title: Tuberculosis susceptibility and protection in children
Authors: Basu Roy, R
Whittaker, E
Seddon, JA
Kampmann, B
Item Type: Journal Article
Abstract: Children represent both a clinically important population susceptible to tuberculosis and a key group in whom to study intrinsic and vaccine-induced mechanisms of protection. After exposure to Mycobacterium tuberculosis, children aged under 5 years are at high risk of progressing first to tuberculosis infection, then to tuberculosis disease and possibly disseminated forms of tuberculosis, with accompanying high risks of morbidity and mortality. Children aged 5–10 years are somewhat protected, until risk increases again in adolescence. Furthermore, neonatal BCG programmes show the clearest proven benefit of vaccination against tuberculosis. Case-control comparisons from key cohorts, which recruited more than 15 000 children and adolescents in total, have identified that the ratio of monocytes to lymphocytes, activated CD4 T cell count, and a blood RNA signature could be correlates of risk for developing tuberculosis. Further studies of protected and susceptible populations are necessary to guide development of novel tuberculosis vaccines that could facilitate the achievement of WHO's goal to eliminate deaths from tuberculosis in childhood.
Issue Date: 1-Mar-2019
Date of Acceptance: 9-Feb-2018
URI: http://hdl.handle.net/10044/1/58075
DOI: https://dx.doi.org/10.1016/S1473-3099(18)30157-9
ISSN: 1473-3099
Publisher: Elsevier
Start Page: e96
End Page: e108
Journal / Book Title: Lancet Infectious Diseases
Volume: 19
Issue: 3
Copyright Statement: © 2018 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: National Institute for Health Research
Funder's Grant Number: SRF-2009-02-07
Keywords: Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
ISONIAZID PREVENTIVE THERAPY
BACILLE CALMETTE-GUERIN
DEVELOPING ACTIVE TUBERCULOSIS
GENOME-WIDE ASSOCIATION
MYCOBACTERIUM-TUBERCULOSIS
CHILDHOOD TUBERCULOSIS
PULMONARY TUBERCULOSIS
IMMUNE-RESPONSES
RISK-FACTORS
SKIN-TEST
Microbiology
1103 Clinical Sciences
1108 Medical Microbiology
Publication Status: Published
Online Publication Date: 2018-10-12
Appears in Collections:Department of Medicine
Faculty of Medicine



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