Chemokine transport dynamics and emerging recognition of their role in immune function

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Title: Chemokine transport dynamics and emerging recognition of their role in immune function
Authors: Moore Jr, JE
Brook, B
Nibbs, RJB
Item Type: Journal Article
Abstract: Leukocyte migration is critically important during all protective and pathological immune and inflammatory responses. Chemokines play fundamental roles in this process, and chemokine concentration gradients stimulate the directional migration of leukocytes. The formation and regulation of these gradients is poorly understood. These are complex processes that depend on the specific properties of each chemokine and interactions between physical, biological and biochemical processes, including production, diffusion, advection, scavenging, post-translational modification, and extracellular matrix (ECM) binding. While some of these mechanisms have been investigated in isolation or limited combinations, more integrative research is required to provide a quantitative knowledge base that explains how chemokine gradients are established and maintained, and how cells respond to, and modify, these gradients.
Issue Date: 20-Mar-2018
Date of Acceptance: 13-Mar-2018
ISSN: 2468-4511
Publisher: Elsevier
Start Page: 90
End Page: 95
Journal / Book Title: Current Opinion in Biomedical Engineering
Volume: 5
Copyright Statement: © 2018 Elsevier Inc. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence
Sponsor/Funder: The Royal Society
Royal Academy Of Engineering
National Institutes of Health
Wellcome Trust
Funder's Grant Number: WM120065
Publication Status: Published
Online Publication Date: 2018-03-20
Appears in Collections:Faculty of Engineering

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