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Phasic stimulation of midbrain dopamine neuron activity reduces salt consumption

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Title: Phasic stimulation of midbrain dopamine neuron activity reduces salt consumption
Authors: Sandhu, EC
Fernando, ABP
Irvine, E
Tossell, K
Kokkinou, M
Glegola, J
Smith, M
Howes, O
Withers, DJ
Ungless, MA
Item Type: Journal Article
Abstract: Salt intake is an essential dietary requirement, but excessive consumption is implicated in hypertension and associated conditions. Little is known about the neural circuit mechanisms that control motivation to consume salt, although the midbrain dopamine system, which plays a key role in other reward-related behaviours, has been implicated. We, therefore, examined the effects on salt consumption of either optogenetic excitation or chemogenetic inhibition of ventral tegmental area (VTA) dopamine neurons in male mice. Strikingly, optogenetic excitation of dopamine neurons decreased salt intake in a rapid and reversible manner, despite a strong salt appetite. Importantly, optogenetic excitation was not aversive, did not induce hyperactivity, and did not alter salt concentration preferences in a need-free state. In addition, we found that chemogenetic inhibition of dopamine neurons had no effect on salt intake. Lastly, optogenetic excitation of dopamine neurons reduced consumption of sucrose following an overnight fast, suggesting a more general role of VTA dopamine neuron excitation in organising motivated behaviors.
Issue Date: 23-Apr-2018
Date of Acceptance: 13-Mar-2018
URI: http://hdl.handle.net/10044/1/58038
DOI: https://dx.doi.org/10.1523/ENEURO.0064-18.2018
ISSN: 2373-2822
Publisher: Society for Neuroscience
Journal / Book Title: eNeuro
Volume: 5
Issue: 2
Copyright Statement: © 2018 Sandhu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
Sponsor/Funder: The Royal Society
Medical Research Council
Funder's Grant Number: UF090017
MC-A654-5QB40
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
appetite
dopamine
salt
VTA
NUCLEUS-ACCUMBENS DOPAMINE
VENTRAL TEGMENTAL AREA
DIETARY-SODIUM INTAKE
FEEDING-BEHAVIOR
TRANSGENIC MICE
DEFICIENT MICE
OB/OB MICE
TRADE-OFF
REWARD
FOOD
Publication Status: Published
Appears in Collections:Clinical Sciences
Imaging Sciences
Molecular Sciences
Faculty of Medicine
Faculty of Natural Sciences



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