Conundrum of the tpeak-tend interval

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Title: Conundrum of the tpeak-tend interval
Authors: Malik, M
Huikuri, H
Lombardi, F
Schmidt, G
Zabel, M
E-Rhythm Study Group of EHRA
Item Type: Journal Article
Abstract: Over the past years, many publications appeared dealing with the clinical utility of the electrocardiographic interval between the peak and the end of the T wave (the Tpe interval). A recently published meta-analysis concluded [1] that the Tpe interval is “a useful risk stratification tool in different diseases and in the general population”. This conclusion broadly agrees with the article by Yu et al in this issue of the Journal [2] who report that prolonged Tpe interval predicts arrhythmic events in the acute phase of ST elevation myocardial infarction. Hence, if quickly scanning through all this, conclusion can easily be made that the usefulness of Tpe interval for the prediction of arrhythmic risk has now been proven beyond reasonable doubt. However, when considering the topic of the usefulness of Tpe interval with proper research care, serious doubts remain. In this text, we therefore comment not only on the report by Yu et al but also on serious shortcomings in the recent meta-analysis by Tse et al [1] and discuss the frequent misunderstanding of the electrophysiologic basis of the Tpe interval. Since some of the enthusiasm for this ECG measurement might have been exaggerated, we intentionally present a critical view of the topic.
Issue Date: 1-May-2018
Date of Acceptance: 26-Feb-2018
DOI: hppts://
ISSN: 1045-3873
Publisher: Wiley
Start Page: 767
End Page: 770
Journal / Book Title: Journal of Cardiovascular Electrophysiology
Volume: 29
Issue: 5
Copyright Statement: © 2018 Wiley Periodicals, Inc. This is the accepted version of the following article, which has been published in final form at:
Sponsor/Funder: British Heart Foundation
Funder's Grant Number: NH/16/2/32499
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
e-Rhythm Study Group of EHRA
1102 Cardiovascular Medicine And Haematology
Cardiovascular System & Hematology
Publication Status: Published
Conference Place: United States
Online Publication Date: 2018-03-07
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine

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