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Lifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study

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Title: Lifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study
Authors: Naudin, S
Li, K
Jaouen, T
Assi, N
Kyrø, C
Tjønneland, A
Overvad, K
Boutron-Ruault, M-C
Rebours, V
Védié, A-L
Boeing, H
Kaaks, R
Katzke, V
Bamia, C
Naska, A
Trichopoulou, A
Berrino, F
Tagliabue, G
Palli, D
Panico, S
Tumino, R
Sacerdote, C
Peeters, PH
Bueno-de-Mesquita, B
Weiderpass Vainio, E
Gram, IT
Skeie, G
Chirlaque, M-D
Rodríguez-Barranco, M
Barricarte, A
Quirós, JR
Dorronsoro, M
Johansson, I
Sund, M
Sternby, H
Bradbury, KE
Wareham, N
Riboli, E
Gunter, M
Brennan, P
Duell, EJ
Ferrari, P
Item Type: Journal Article
Abstract: Recent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In this study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer-free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and their 95% confidence interval (CI). Alcohol intake was positively associated with PC risk in men. Associations were mainly driven by extreme alcohol levels, with HRs comparing heavy drinkers (>60 g/day) to the reference category (0.1-4.9 g/day) equal to 1.77 (95% CI: 1.06, 2.95) and 1.63 (95% CI: 1.16, 2.29) for lifetime and baseline alcohol, respectively. Baseline alcohol intakes from beer (>40 g/day) and spirits/liquors (>10 g/day) showed HRs equal to 1.58 (95% CI: 1.07, 2.34) and 1.41 (95% CI: 1.03, 1.94), respectively, compared to the reference category (0.1-2.9 g/day). In women, HR estimates did not reach statistically significance. The alcohol and PC risk association was not modified by smoking status. Findings from a large prospective study suggest that baseline and lifetime alcohol intakes were positively associated with PC risk, with more apparent risk estimates for beer and spirits/liquors than wine intake. This article is protected by copyright. All rights reserved.
Issue Date: 15-Aug-2018
Date of Acceptance: 2-Feb-2018
URI: http://hdl.handle.net/10044/1/57840
DOI: https://dx.doi.org/10.1002/ijc.31367
ISSN: 0020-7136
Publisher: Wiley
Start Page: 801
End Page: 812
Journal / Book Title: International Journal of Cancer
Volume: 143
Issue: 4
Copyright Statement: © 2018 UICC. This is the pre-peer reviewed version of the following article, which has been published in final form at https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31367
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: SP23-CT-2005-006438
Keywords: 1112 Oncology And Carcinogenesis
Oncology & Carcinogenesis
Publication Status: Published
Conference Place: United States
Online Publication Date: 2018-03-09
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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