Auxetic cardiac patches with tunable mechanical and conductive properties toward treating myocardial infarction

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Title: Auxetic cardiac patches with tunable mechanical and conductive properties toward treating myocardial infarction
Author(s): Kapnisi, M
Mansfield, C
Marijon, C
Guex, AG
Perbellini, F
Bardi, I
Humphrey, EJ
Puetzer, J
Mawad, D
Koutsogeorgis, DC
Stuckey, DJ
Terracciano, CM
Harding, SE
Stevens, MM
Item Type: Journal Article
Abstract: An auxetic conductive cardiac patch (AuxCP) for the treatment of myocardial infarction (MI) is introduced. The auxetic design gives the patch a negative Poisson's ratio, providing it with the ability to conform to the demanding mechanics of the heart. The conductivity allows the patch to interface with electroresponsive tissues such as the heart. Excimer laser microablation is used to micropattern a re‐entrant honeycomb (bow‐tie) design into a chitosan‐polyaniline composite. It is shown that the bow‐tie design can produce patches with a wide range in mechanical strength and anisotropy, which can be tuned to match native heart tissue. Further, the auxetic patches are conductive and cytocompatible with murine neonatal cardiomyocytes in vitro. Ex vivo studies demonstrate that the auxetic patches have no detrimental effect on the electrophysiology of both healthy and MI rat hearts and conform better to native heart movements than unpatterned patches of the same material. Finally, the AuxCP applied in a rat MI model results in no detrimental effect on cardiac function and negligible fibrotic response after two weeks in vivo. This approach represents a versatile and robust platform for cardiac biomaterial design and could therefore lead to a promising treatment for MI.
Publication Date: 24-May-2018
Date of Acceptance: 5-Mar-2018
URI: http://hdl.handle.net/10044/1/57834
DOI: https://dx.doi.org/10.1002/adfm.201800618
ISSN: 1616-301X
Publisher: Wiley
Journal / Book Title: Advanced Functional Materials
Volume: 28
Issue: 21
Copyright Statement: © 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Commission of the European Communities
Medical Research Council (MRC)
Medical Research Council (MRC)
British Heart Foundation
Wellcome Trust
British Heart Foundation
Kusuma Trust UK
Funder's Grant Number: PIIF-GA-2012-328897
MR/L012677/1
MR/K026682/1
RM/13/1/30157
098411/Z/12/Z
RM/17/1/33377
MMRE_P74027
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
auxetic materials
biomaterials
cardiac patches
doped-conjugated polymers
re-entrant honeycombs
POISSONS RATIO
BIOMATERIALS
SCAFFOLD
HONEYCOMBS
HEART
auxetic materials
biomaterials
cardiac patches
doped-conjugated polymers
re-entrant honeycombs
03 Chemical Sciences
09 Engineering
02 Physical Sciences
Materials
Publication Status: Published
Article Number: 1800618
Open Access location: https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201800618
Online Publication Date: 2018-04-10
Appears in Collections:Faculty of Engineering
Materials
National Heart and Lung Institute
Faculty of Medicine
Faculty of Natural Sciences



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