Road traffic noise, air pollution and incident cardiovascular disease: a joint analysis of the HUNT, EPIC-Oxford and UK Biobank cohorts

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Title: Road traffic noise, air pollution and incident cardiovascular disease: a joint analysis of the HUNT, EPIC-Oxford and UK Biobank cohorts
Authors: Cai, Y
Hansell, A
Hodgson, S
Elliott, P
Fecht, D
Gulliver, J
Key, T
De Hoogh, K
Hveem, K
Morley, D
Vienneau, D
Blangiardo, M
Item Type: Journal Article
Abstract: Background : This study aimed to investigate the effects of long - term exposure to road traffic noise and air pollution on incident cardiovascular disease ( CVD ) in three large cohort s : HUNT, EPIC - Oxford and UK Biobank. Methods : In pooled complete - case sample of the three cohorts from Norway and the United Kingdom (N= 355 ,7 32 ) , 21,081 incident all CVD cases including 5,259 ischemic heart disease ( IHD ) and 2, 871 cerebrovascular cases were ascertained between baseline ( 199 3 - 2010 ) and end of follow - up ( 2008 - 201 3 ) through medical record linkage . Annual mean 24 - hour weighted road traffic noise (L den ) and air pollution ( particulate matter with aerodynamic diameter ≤10 μm [ PM 10 ] , ≤2.5 μm [PM 2.5 ] and nitrogen 39 dioxide [ NO 2 ]) exposure at baseline address was modelled using a simplified version of the Common Noise Assessment Methods in Europe (CNOSSOS - EU) and European - wide Land Use Regression model s . Individual - level covariate data were harmonised and physically p ooled across the three cohorts. Analysis was via Cox proportional hazard model with mutual adjustment s for both noise and air pollution and potential confounders . Results : No significant associations were found between annual mean L den and incident CVD, IHD or cerebrovascular disease in the overall population except that the a ssociation with incident IHD w as significant among current - smokers . In the fully adjusted models including adjustment for L den , an interquartile range (IQR) higher PM 10 (4.1μg/m 3 ) o r PM 2.5 (1.4μg/m 3 ) was associated with a 5.8% (95%CI: 2.5% - 9.3%) and 3.7% (95%CI: 0.2% - 7.4%) higher risk for all incident CVD respectively . No significant associations were found between NO 2 and any of the CVD outcomes. Conclusions: We found suggestiv e evidence of a possible association between road traffic noise and incident IHD, consistent with current literature. Long-term particulate air pollution exposure, even at concentrations below current European air quality standards , was significantly associated with incident CVD.
Date of Acceptance: 27-Feb-2018
URI: http://hdl.handle.net/10044/1/57346
ISSN: 0160-4120
Publisher: Elsevier
Journal / Book Title: Environment International
Sponsor/Funder: EU FP7
Public Health England
Medical Research Council
Funder's Grant Number: 6509268
Keywords: MD Multidisciplinary
Environmental Sciences
Publication Status: Accepted
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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