Antimicrobial resistance with Streptococcus pneumoniae in the United States, 1997-98

Title: Antimicrobial resistance with Streptococcus pneumoniae in the United States, 1997-98
Author(s): Doern, GV
Brueggemann, AB
Huynh, H
Wingert, E
Rhomberg, P
Item Type: Journal Article
Abstract: From November 1997 to April 1998, 1,601 clinical isolates of Streptococcus pneumoniae were obtained from 34 U.S. medical centers. The overall rate of strains showing resistance to penicillin was 29.5%, with 17.4% having intermediate resistance. Multidrug resistance, defined as lack of susceptibility to penicillin and at least two other non-ß-lactam classes of antimicrobial drugs, was observed in 16.0% of isolates. Resistance to all 10 ß-lactam drugs examined in this study was directly related to the level of penicillin resistance. Penicillin resistance rates were highest in isolates from middle ear fluid and sinus aspirates of children <5 years of age and from patients in ambulatory-care settings. Twenty-four of the 34 medical centers in this study had participated in a similar study 3 years before. In 19 of these 24 centers, penicillin resistance rates increased 2.9% to 39.2%. Similar increases were observed with rates of resistance to other antimicrobial drugs.
Publication Date: 1-Nov-1999
Date of Acceptance: 1-Nov-1999
URI: http://hdl.handle.net/10044/1/57255
DOI: https://dx.doi.org/10.3201/eid0506.990603
ISSN: 1080-6040
Publisher: CENTER DISEASE CONTROL
Start Page: 757
End Page: 765
Journal / Book Title: EMERGING INFECTIOUS DISEASES
Volume: 5
Issue: 6
Copyright Statement: © 1999 The Author(s). This article is open access under the Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0/)
Copyright Statement: © 1999 The Author(s). This article is open access under the Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0/)
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
PENICILLIN-BINDING PROTEIN-2X
SURVEILLANCE
PREVALENCE
Child, Preschool
Drug Resistance, Multiple
Humans
Microbial Sensitivity Tests
Penicillin Resistance
Streptococcus pneumoniae
United States
Humans
Streptococcus pneumoniae
Microbial Sensitivity Tests
Penicillin Resistance
Drug Resistance, Multiple
Child, Preschool
United States
1108 Medical Microbiology
1117 Public Health And Health Services
1103 Clinical Sciences
Microbiology
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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