Single cell expression quantitative trait loci and complex traits

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Title: Single cell expression quantitative trait loci and complex traits
Authors: Petretto, E
Item Type: Journal Article
Abstract: The recently developed ability to quantify mRNA abundance and noise in single cells has allowed the effect of heritable variations on gene function to be re-evaluated. A recent study has shown that major sources of variation are masked when gene expression is averaged over many cells. Heritable variations that determine single-cell expression phenotypes may exert a regulatory function in specific cellular processes underlying disease. Masked effects on gene expression should therefore be modeled, not ignored.
Issue Date: 20-Aug-2013
Date of Acceptance: 1-Aug-2013
URI: http://hdl.handle.net/10044/1/57226
DOI: https://dx.doi.org/10.1186/gm476
ISSN: 1756-994X
Publisher: BioMed Central
Journal / Book Title: Genome Medicine
Volume: 5
Copyright Statement: © BioMed Central Ltd 2013. This article is available under the Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0/legalcode)
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
0604 Genetics
1103 Clinical Sciences
Publication Status: Published
Article Number: ARTN 72
Appears in Collections:Clinical Sciences
Molecular Sciences
Faculty of Medicine



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